N-cyanoaryl-nitrogen heterocycles

ABSTRACT

The invention relates to new N-cyanoaryl-nitrogen hetero-cycles of the general formula (I) ##STR1## in which R 1 , R 2 , R 3 , R 4  and Z have the meanings given in the description, 
     to a plurality of processes for their preparation, to their use as herbicides and to novel intermediates.

This is a Continuation of application Ser. No. 08/877,678, filed on Jun. 17, 1997, now abandoned, which is a Divisional of application Ser. No. 08/316,618, filed on Sep. 30, 1994, now U.S. Pat. No. 5,681,794, which is a Continuation in Part of application Ser. No. 08/289,071, filed on Aug. 11, 1994, now U.S. Pat. No. 5,593,945. This is a continuation-in-part of application Ser. No. 08/289,071, filed Aug. 11, 1994, now pending.

The invention relates to new N-cyanoaryl-niitrogen hetero-cycles, to a plurality of processes for their preparation, to their use as herbicides, and to new intermediates.

It has already been disclosed that certain N-cyanoaryl-nitrogen heterocycles have herbicidal properties (cf. WO 91/00278, WO 92/11244, DE 4237920, EP 408382/U.S. Pat. No. 5,084,084, EP 438209, EP 473551).

However, the herbicidal activity or the compatibility of the previously known N-cyanoaryl-nitrogen heterocycles with crop plants are not entirely satisfactory.

The new N-cyanoaryl-nitrogen heterocycles of the general formula (I) ##STR2## in which

R¹ represents hydrogen or halogen,

R² represents halogen, cyano, amino or the group

--N(A¹) SO₂ A,

where A represents in each case optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl,

and A¹ represents hydrogen or optionally substituted alkyl, alkenyl, alkinyl, alkoxy, alkylcarbonyl, alkoxycarbonyl, arylcarbonyl, arylalkylcarbonyl or aryloxycarbonyl,

R³ represents hydrogen, halogen, cyano or optionally substituted alkyl,

R⁴ represents optionally substituted alkyl or together with R³ represents alkanediyl,

Z represents one of the groups below ##STR3## in which R⁵ represents hydrogen, amino (bonded to N only) or in each case optionally substituted alkyl, alkenyl, alkinyl, alkylcarbonyl or alkoxycarbonyl,

and their salts, the compounds 1-(4-cyano-3-ethylsulphonylamino-phenyl)-3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H)-pyrimidine, 1-(4-cyano-3-n-propyl-sulphonylamino-phenyl)-3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H)-pyrimidine, 1-(4-cyano-3-isopropyl-sulphonylamino-phenyl)-3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H) -pyrimidine, 1-(4-cyano-5-ethyl-sulphonylamino-2-fluoro-phenyl)-3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H)-pyrimidine, 1-(4-cyano-5-n-propylsulphonylamino-2-fluoro-phenyl)-3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H)-pyrimidine and 1-(4-cyano-5-isopropylsulphonylamino-2-fluoro-phenyl)-3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H)-pyrimidine--all disclosed in U.S. Pat. No. 5,084,084--being excepted by disclaimer,

have now been found.

Thus, the general formula (I) represents the isomeric compounds of the general formulae (IA) and (IB) below ##STR4##

The new N-cyanoaryl-nitrogen heterocycles of the general formula (I) and salts thereof are obtained when,

(a) to prepare compounds of the formulae (IA) and (IB) in which R⁵ represents hydrogen and R¹, R², R³ and R⁴ have the abovementioned meanings,

Aminoalkenoic esters of the general formula (II) ##STR5## in which R³ and R⁴ have the abovementioned meanings and

R represents alkyl, aryl or arylalkyl are reacted with cyanoaryl isocyanates of the general formula (III) ##STR6## in which R¹ and R² have the abovementioned meanings, or with cyanoarylylurethane (cyanoaryl-carbamates) of the general formula (IV) ##STR7## in which R¹ and R² have the abovementioned meanings and

R represents alkyl, aryl or arylalkyl, if appropriate in the presence of a reaction auxiliary and if appropriate in the presence of a diluent, or when,

(b) to prepare compounds of the formulae (IA) and/or (IB) in which R⁵ represents in each case optionally substituted alkyl, alkenyl, alkinyl, alkylcarbonyl or alkoxycarbonyl and R¹, R², R³ and R⁴ have the abovementioned meanings,

N-cyanoaryl-nitrogen heterocycles of the general formula (IA) or (IB)

in which R⁵ represents hydrogen and R¹, R², R³ and R⁴ have the abovementioned meanings, are reacted with alkylating agents or acylating agents of the general formula (V) or (VI)

    X--R.sup.5                                                 (V)

    R.sup.5 --O--SO.sub.2 --O--R.sup.5                         (VI)

in which R⁵ represents in each case optionally substituted alkyl, alkenyl, alkinyl, alkylcarbonyl or alkoxycarbonyl and X in formula (V) represents halogen,

if appropriate in the presence of an acid acceptor and if appropriate in the presence of a diluent, or when,

(c) to prepare compounds of the formula (I) in which R² represents amino or the group --N(A¹)SO₂ A and A, A¹, R¹, R³, R⁴ and Z have the abovementioned meanings,

N-cyanoaryl-nitrogen heterocycles of the general formula (I) in which R² represents halogen and R¹, R³, R⁴ and Z have the abovementioned meanings, are reacted with ammonia or with anodes of the general formula (VII)

    HN(A.sup.1)SO.sub.2 A                                      (AI)

in which

A and Al have the abovementioned meanings, if appropriate in the presence of an acid acceptor and if appropriate in the presence of a diluent.

The compounds of the formula (IA) in which R⁵ represents amino can be prepared in a known manner by reacting corresponding compounds of the formula (IA), in which R⁵ represents hydrogen, with aminating agents, such as, for example, 1-aminooxy-2,4-dinitro-benzene (ADNB) in accordance with the equation below (cf. EP 476697, Example 4): ##STR8##

The new N-cyanoaryl-nitrogen heterocycles of the general formula (I) and salts thereof are distinguished by a powerful herbicidal activity.

In the definitions, the saturated or unsaturated hydrocarbon chains, such as alkyl, alkanediyl, alkenyl or alkinyl, are in each case straight chain or branched. Halogen generally represents fluorine, chlorine, bromine or iodine, preferably fluorine, chlorine or bromine, in particular fluorine or chlorine.

The invention preferably relates to compounds of the formula (I) in which

R¹ represents hydrogen, fluorine, chlorine or bromine,

R² represents fluorine, chlorine, bromine, cyano, amino or the group --N(A¹)SO₂ A in which

A represents a radical from the series comprising alkyl, alkenyl or alkinyl, each of which has up to 10 carbon atoms and each of which is optionally substituted by fluorine, chlorine, bromine, cyano or C₁ -C₄ -alkoxy,

A furthermore represents cycloalkyl or cycloalkyl-alkyl, each of which has 3 to 8 carbon atoms in the cycloalkyl moiety and, if appropriate, 1 to 4 carbon atoms in the alkyl moiety and each of which is optionally substituted by fluorine, chlorine, bromine, cyano or C₁ -C₄ -alkyl,

A furthermore represents aryl or arylalkyl, each of which has 6 or 10 carbon atoms in the aryl moiety and 1 to 4 carbon atoms in the alkyl moiety and each of which is optionally substituted by fluorine, chlorine, bromine, cyano, nitro, carboxyl, carbamoyl, by C₁ -C₄ -alkyl, C₁ -C₄ -alkoxy, C₁ -C₄ -alkyl-thio, C₁ -C₄ -alkylsulphinyl or C₁ -C₄ -alkylsulphonyl (each of which is optionally substituted by fluorine and/or chlorine), by dimethylaminosulphonyl or diethylaminosulphonyl, by C₁ -C₄ -alkoxycarbonyl (which is optionally substituted by fluorine, chlorine, bromine, methoxy or ethoxy), by phenyl, phenyloxy or phenylthio (each of which is optionally substituted by fluorine, chlorine, bromine, cyano, methyl, methoxy, trifluoromethyl and/or trif luoromethoxy),

A furthermore represents heterocyclyl or heterocyclylalkyl, each of which has 2 to 6 carbon atoms and 1 to 4 nitrogen atoms and/or 1 or 2 oxygen or sulphur atoms in the saturated or unsaturated heterocyclyl moiety and optionally 1 to 4 carbon atoms in the alkyl moiety and each of which is optionally substituted by fluorine, chlorine, bromine, cyano, nitro, carboxyl, carbamoyl, by C₁ -C₄ -alkyl, C₁ -C₄ -alkoxy, C₁ -C₄ -alkylthio, C₁ -C₄ -alkylsulphinyl, C₁ -C₄ -alkylsulphonyl or C₁ -C₄ -alkoxycarbonyl (each of which is optionally substituted by fluorine and/or chlorine), by phenyl, phenoxy or phenylthio (each of which is optionally substituted by fluorine, chlorine, bromine, cyano, methyl, methoxy, trifluoromethyl and/or trifluoromethoxy), and

A¹ represents hydrogen or alkyl, alkenyl, alkinyl, alkoxy, alkylcarbonyl or alkoxycarbonyl, each of which has up to 6 carbon atoms and each of which is optionally substituted by halogen or C₁ -C₄ -alkoxy, or represents phenylcarbonyl, naphthylcarbonyl, phenylmethylcarbonyl, naphthylmethylcarbonyl, phenoxycarbonyl or naphthyloxycarbonyl (each of which is optionally substituted by fluorine, chlorine, bromine, cyano, methyl, methoxy, trifluoromethyl and/or trifluoromethoxy),

R³ represents hydrogen, fluorine, chlorine, bromine, cyano or alkyl having 1 to 6 carbon atoms which is optionally substituted by fluorine and/or chlorine,

R⁴ represents alkyl having 1 to 6 carbon atoms which is optionally substituted by fluorine, chlorine, bromine, methoxy or ethoxy,

or together with R³ represents alkanediyl having 2 to 8 carbon atoms, and

Z represents one of the groups below ##STR9## in which R⁵ represents hydrogen or Amino, or represents alkyl, alkenyl, alkinyl, alkylcarbonyl or alkoxycarbonyl, each of which has up to 6 carbon atoms and each of which is optionally substituted by fluorine, chlorine, bromine, cyano, C₁ -C₄ -alkoxy, C₁ -C₄ -alkyl-carbonyl or C₁ -C₄ -alkoxy-carbonyl, and salts thereof with bases, such as, for example, sodium, potassium or calcium hydroxide, hydride, amide or carbonate, sodium or potassium C₁ -C₄ -alkanolates, ammonia, C₁ -C₄ -alkylamines, di-(C₁ -C₄ -alkyl) -amines, tri- (C₁ -C₄ -alkyl) -amines or with tris-(2-hydroxyethyl)amine, the abovementioned compounds being excepted.

The invention particularly relates to compounds of the formula (I) in which

R¹ represents hydrogen, fluorine or chlorine,

R² represents fluorine, chlorine, bromine, cyano, amino or the group --N(A¹)SO₂ A in which

A represents methyl, ethyl, n- or i-propyl, n-, i-, s- or t-butyl or n-, i-, s- or t-pentyl, each of which is optionally substituted by fluorine or chlorine,

A furthermore represents cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl or cyclohexylmethyl, each of which is optionally substituted by fluorine, chlorine, bromine, methyl and/or ethyl,

A furthermore represents phenyl, naphthyl, phenylmethyl or phenylethyl, each of which is optionally substituted by fluorine, chlorine, bromine, cyano, nitro, carboxy, methyl, trifluoromethyl, methoxy, ethoxy, difluoromethoxy, trifluoromethoxy, methylthio, ethylthio, methylsulphinyl, ethylsulphinyl, methylsulphonyl, ethylsulphonyl, dimethylaminosulphonyl, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl or phenyl,

A furthermore represents thienyl, pyrazolyl or pyridyl, each of which is optionally substituted by fluorine, chlorine, bromine, cyano, methyl, ethyl, trifluoromethyl, methoxy, ethoxy, methylthio, ethylthio, methylsulphinyl, ethylsulphinyl, methylsulphonyl, ethylsulphonyl, methoxycarbonyl or ethoxycarbonyl, and

A¹ represents hydrogen or methyl; ethyl, n- or i-propyl, n-, i- or s-butyl, propenyl, butenyl, propinyl, butinyl, methoxy, ethoxy, n- or i-propoxy, n-, i-, s- or t-butoxy, acetyl, propionyl, methoxycarbonyl or ethoxycarbonyl, each of which is optionally substituted by fluorine, chlorine, methoxy or ethoxy, or represents phenylcarbonyl or phenoxycarbonyl,

R³ represents hydrogen, fluorine, chlorine, bromine, methyl, trifluoromethyl, ethyl or n- or i-propyl,

R₄ represents methyl, ethyl, n- or i-propyl, each of which is optionally substituted by fluorine or chlorine,

or together with R³ represents trimethylene or tetramethylene, and

Z represents one of the groups below ##STR10## in which R⁵ represents hydrogen, amino or methyl, ethyl, n- or i-propyl, n-, i- or s-butyl, propenyl, butenyl, propinyl, butinyl, acetyl, propionyl, methoxycarbonyl or ethoxycarbonyl, each of which is optionally substituted by fluorine, chlorine or cyano, and salts thereof with bases, such as, for example, sodium, potassium or calcium hydroxide, hydride, amide or carbonate, sodium or potassium C₁ -C₄ -alkanolates, ammonia, C₁ -C₄ -alkylamines, di- (C₁ -C₄ -alkyl)-amines, tri- (C₁ -C₄ -alkyl)-amines or with tris-(2-hydroxyethyl)amine, the above-mentioned compounds being excepted.

A very particularly preferred group of compounds of the formula (I) are those compounds of the formula (IA) in which R¹, R², R³, R⁴ and R⁵ have the meaning given above as being particularly preferred.

The above-listed general radical definitions, or those given in preference ranges, apply both to the end products of the formula (I) and also, correspondingly, to the starting materials or intermediates required in each case for the preparation.

These radical definitions can be combined with each other as desired, that is to say combinations between the ranges of preferred compounds which have been given are also possible.

Examples of the compounds of the formula (I) according to the invention are listed in Table 1 below.

                                      TABLE 1                                      __________________________________________________________________________     Examples of the compounds of the formula (I)                                   R.sup.1                                                                            R.sup.2          R.sup.3                                                                             R.sup.4                                                                             R.sup.5                                         __________________________________________________________________________     F   F                H    CH.sub.3                                                                            H                                               F   F                H    CH.sub.3                                                                            CH.sub.3                                        F   F                H    CH.sub.3                                                                            CHF.sub.2                                       F   F                H    CH.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    CH.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 CH.sub.3                                                                             H    CH.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 CH.sub.3                                                                             H    CH.sub.3                                                                            NH.sub.2                                        H   NHSO.sub.2 CH.sub.3                                                                             H    CH.sub.3                                                                            NH.sub.2                                        F   F                H    CF.sub.3                                                                            CH.sub.3                                        F   F                H    CF.sub.3                                                                            C.sub.3 H.sub.7                                 Cl  F                CH.sub.3                                                                            CF.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 CH.sub.3                                                                             H    CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    CF.sub.3                                                                            C.sub.2 H.sub.5                                      ##STR11##       H    CF.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 CH.sub.3                                                                             H    CF.sub.3                                                                            CH.sub.2 --C.tbd.CH                             F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    CF.sub.3                                                                             ##STR12##                                      F   NHSO.sub.2 CH.sub.3                                                                             H    CF.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    CH.sub.2 Cl                                                                         CH.sub.3                                        F   F                H    CF.sub.2 CF.sub.3                                                                   H                                               F   F                H    CF.sub.2 CF.sub.3                                                                   CH.sub.3                                        H   F                H    CF.sub.2 CF.sub.3                                                                   C.sub.2 H.sub.5                                 H   F                H    CF.sub.2 CF.sub.3                                                                   CH.sub.2 CH═CH.sub.2                        F   NHSO.sub.2 CH.sub.3                                                                             H    CF.sub.2 CF.sub.3                                                                   CH.sub.3                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    CF.sub.2 CF.sub.3                                                                   CH.sub.3                                        F   F                H    CHF.sub.2                                                                           H                                               F   F                H    CHF.sub.2                                                                           CH.sub.3                                        F   F                H    CHF.sub.2                                                                           CHF.sub.2                                       F   F                H    CHF.sub.2                                                                           NH.sub.2                                        F   NHSO.sub.2 CH.sub.3                                                                             H    CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 CH.sub.3                                                                             H    CHF.sub.2                                                                           CHF.sub.2                                       F   NHSO.sub.2 CH.sub.3                                                                             H    CHF.sub.2                                                                           NH.sub.2                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      Cl   CHF.sub.2                                                                           CH.sub.2 CH═CH.sub.2                        F   NHSO.sub.2 CF.sub.3                                                                             H    CH.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 CH.sub.3                                                                             H    CF.sub.3                                                                            H                                               F                                                                                   ##STR13##       H    CF.sub.3                                                                            CH.sub.3                                        F   .sup.⊖ NSO.sub.2 CH.sub.3 K.sup.⊕                                                   H    CF.sub.3                                                                            CH.sub.3                                        F   .sup.⊖ NSO.sub.2 C.sub.2 H.sub.5 Na.sup.⊕                                           H    CF.sub.3                                                                            CH.sub.3                                        F   .sup.⊖ NSO.sub.2 C.sub.3 H.sub.7 -n K.sup.⊖                                     H    CF.sub.3                                                                            CH.sub.3                                        F   .sup.⊖ NSO.sub.2 C.sub.3 H.sub.7 -i Na.sup.⊕                                        H    CF.sub.3                                                                            CH.sub.3                                        F   .sup.⊖ NSO.sub.2 CH.sub.3 K.sup.⊖                                               H    CF.sub.3                                                                            CH.sub.3                                        H   NHSO.sub.2 CH.sub.3                                                                             H    CH.sub.3                                                                            CH.sub.3                                        H   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    CH.sub.3                                                                            CH.sub.3                                        H   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    CH.sub.3                                                                            CH.sub.3                                        H   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   H    CH.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR14##       H    CH.sub.3                                                                            CH.sub.3                                        H   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   H    CH.sub.3                                                                            CH.sub.3                                        H   NHSO.sub.2 C.sub.6 H.sub.5                                                                      H    CH.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR15##       H    CH.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 CH.sub.3                                                                             H    CH.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    CH.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    CH.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   H    CH.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR16##       H    CH.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   H    CH.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.6 H.sub.5                                                                      H    CH.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR17##       H    CH.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 CH.sub.3                                                                             CH.sub.3                                                                            CH.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      CH.sub.3                                                                            CH.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   CH.sub.3                                                                            CH.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   CH.sub.3                                                                            CH.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR18##       CH.sub.3                                                                            CH.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   CH.sub.3                                                                            CH.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.6 H.sub.5                                                                      CH.sub.3                                                                            CH.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR19##       CH.sub.3                                                                            CH.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 CH.sub.3                                                                             Cl   CH.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      Cl   CH.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   Cl   CH.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   Cl   CH.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR20##       Cl   CH.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   Cl   CH.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.6 H.sub.5                                                                      Cl   CH.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR21##       Cl   CH.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 CH.sub.3                                                                             F    CH.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      F    CH.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   F    CH.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   F    CH.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR22##       F    CH.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   F    CH.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.6 H.sub.5                                                                      F    CH.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR23##       F    CH.sub.3                                                                            CH.sub.3                                        H   NHSO.sub.2 CH.sub.3                                                                             H    CH.sub.3                                                                            CHF.sub.2                                       H   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    CH.sub.3                                                                            CHF.sub.2                                       H   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    CH.sub.3                                                                            CHF.sub.2                                       H   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   H    CH.sub.3                                                                            CHF.sub.2                                       H                                                                                   ##STR24##       H    CH.sub.3                                                                            CHF.sub.2                                       H   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   H    CH.sub.3                                                                            CHF.sub.2                                       H   NHSO.sub.2 C.sub.6 H.sub.5                                                                      H    CH.sub.3                                                                            CHF.sub.2                                       H                                                                                   ##STR25##       H    CH.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 CH.sub.3                                                                             H    CH.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    CH.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    CH.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   H    CH.sub.3                                                                            CHF.sub.2                                       F                                                                                   ##STR26##       H    CH.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   H    CH.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.6 H.sub.5                                                                      H    CH.sub.3                                                                            CHF.sub.2                                       F                                                                                   ##STR27##       H    CH.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 CH.sub.3                                                                             CH.sub.3                                                                            CH.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      CH.sub.3                                                                            CH.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   CH.sub.3                                                                            CH.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   CH.sub.3                                                                            CH.sub.3                                                                            CHF.sub.2                                       F                                                                                   ##STR28##       CH.sub.3                                                                            CH.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   CH.sub.3                                                                            CH.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.6 H.sub.5                                                                      CH.sub.3                                                                            CH.sub.3                                                                            CHF.sub.2                                       F                                                                                   ##STR29##       CH.sub.3                                                                            CH.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 CH.sub.3                                                                             Cl   CH.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      Cl   CH.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   Cl   CH.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   Cl   CH.sub.3                                                                            CHF.sub.2                                       F                                                                                   ##STR30##       Cl   CH.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   Cl   CH.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.6 H.sub.5                                                                      Cl   CH.sub.3                                                                            CHF.sub.2                                       F                                                                                   ##STR31##       Cl   CH.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 CH.sub.3                                                                             F    CH.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      F    CH.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   F    CH.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   F    CH.sub.3                                                                            CHF.sub.2                                       F                                                                                   ##STR32##       F    CH.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   F    CH.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.6 H.sub.5                                                                      F    CH.sub.3                                                                            CHF.sub.2                                       F                                                                                   ##STR33##       F    CH.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 CH.sub.3                                                                             H    CH.sub.3                                                                            C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    CH.sub.3                                                                            C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    CH.sub.3                                                                            C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   H    CH.sub.3                                                                            C.sub.2 H.sub.5                                 F                                                                                   ##STR34##       H    CH.sub.3                                                                            C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   H    CH.sub.3                                             F   NHSO.sub.2 C.sub.6 H.sub.5                                                                      H    CH.sub.3                                                                            C.sub.2 H.sub.5                                 F                                                                                   ##STR35##       H    CH.sub.3                                                                            C.sub.2 H.sub.5                                 H   NHSO.sub.2 CH.sub.3                                                                             H    CH.sub.3                                                                            NH.sub.2                                        H   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    CH.sub.3                                                                            NH.sub.2                                        H   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    CH.sub.3                                                                            NH.sub.2                                        H   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   H    CH.sub.3                                                                            NH.sub.2                                        H                                                                                   ##STR36##       H    CH.sub.3                                                                            NH.sub.2                                        H   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   H    CH.sub.3                                                                            NH.sub.2                                        H   NHSO.sub.2 C.sub.6 H.sub.5                                                                      H    CH.sub.3                                                                            NH.sub.2                                        H                                                                                   ##STR37##       H    CH.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 CH.sub.3                                                                             H    CH.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    CH.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    CH.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   H    CH.sub.3                                                                            NH.sub.2                                        F                                                                                   ##STR38##       H    CH.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   H    CH.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 C.sub.6 H.sub.5                                                                      H    CH.sub.3                                                                            NH.sub.2                                        F                                                                                   ##STR39##       H    CH.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 CH.sub.3                                                                             CH.sub.3                                                                            CH.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      CH.sub.3                                                                            CH.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   CH.sub.3                                                                            CH.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   CH.sub.3                                                                            CH.sub.3                                                                            NH.sub.2                                        F                                                                                   ##STR40##       CH.sub.3                                                                            CH.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   CH.sub.3                                                                            CH.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 C.sub.6 H.sub.5                                                                      CH.sub.3                                                                            CH.sub.3                                                                            NH.sub.2                                        F                                                                                   ##STR41##       CH.sub.3                                                                            CH.sub.3                                                                            NH.sub.2                                        H   NHSO.sub.2 CH.sub.3                                                                             H    CF.sub.3                                                                            CH.sub.3                                        H   NHSO.sub.2 CF.sub.3                                                                             H    CF.sub.3                                                                            CH.sub.3                                        H   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    CF.sub.3                                                                            CH.sub.3                                        H   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    H    CF.sub.3                                                                            CH.sub.3                                        H   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    CF.sub.3                                                                            CH.sub.3                                        H   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR42##       H    CF.sub.3                                                                            CH.sub.3                                        H   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        H    CF.sub.3                                                                            CH.sub.3                                        H   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   H    CF.sub.3                                                                            CH.sub.3                                        H   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 H    CF.sub.3                                                                            CH.sub.3                                        H   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 H    CF.sub.3                                                                            CH.sub.3                                        H   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR43##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR44##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR45##       H    CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 CH.sub.3                                                                             H    CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 CF.sub.3                                                                             H    CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    H    CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR46##       H    CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        H    CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   H    CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 H    CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 H    CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR47##       H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR48##       H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR49##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR50##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR51##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR52##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR53##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR54##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR55##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR56##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR57##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR58##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR59##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR60##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR61##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR62##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR63##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR64##       H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR65##       H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR66##       H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR67##       H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR68##       H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR69##       H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR70##       H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR71##       H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR72##       H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR73##       H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR74##       H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR75##       H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR76##       H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR77##       H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR78##       H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR79##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR80##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR81##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR82##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR83##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR84##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR85##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR86##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR87##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR88##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR89##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR90##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR91##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR92##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR93##       H    CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR94##       H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR95##       H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR96##       H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR97##       H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR98##       H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR99##       H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR100##      H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR101##      H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR102##      H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR103##      H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR104##      H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR105##      H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR106##      H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR107##      H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR108##      H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR109##      H    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR110##      H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 F                                                                                   ##STR111##      H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 F                                                                                   ##STR112##      H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 F                                                                                   ##STR113##      H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 F                                                                                   ##STR114##      H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 F                                                                                   ##STR115##      H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 F                                                                                   ##STR116##      H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 F                                                                                   ##STR117##      H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 F                                                                                   ##STR118##      H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 F                                                                                   ##STR119##      H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 F                                                                                   ##STR120##      H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 F                                                                                   ##STR121##      H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 F                                                                                   ##STR122##      H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 F                                                                                   ##STR123##      H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 F                                                                                   ##STR124##      H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 H   NHSO.sub.2 CH.sub.3                                                                             H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 H   NHSO.sub.2 CF.sub.3                                                                             H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 H   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 H   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 H   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 H   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 H                                                                                   ##STR125##      H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 H   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 H   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 H   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 H   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 H   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 H                                                                                   ##STR126##      H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 H                                                                                   ##STR127##      H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 H                                                                                   ##STR128##      H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 F   NHSO.sub.2 CH.sub.3                                                                             H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 F   NHSO.sub.2 CF.sub.3                                                                             H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 F                                                                                   ##STR129##      H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 F                                                                                   ##STR130##      H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 F                                                                                   ##STR131##      H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 F                                                                                   ##STR132##      H    CF.sub.3                                                                            C.sub.2 H.sub.5                                 H   NHSO.sub.2 CH.sub.3                                                                             CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        H   NHSO.sub.2 CF.sub.3                                                                             CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        H   NHSO.sub.2 C.sub.2 H.sub.5                                                                      CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        H   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        H   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        H   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR133##      CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        H   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        H   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        H   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        H   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        H   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR134##      CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR135##      CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        H                                                                                   ##STR136##      CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 CH.sub.3                                                                             CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 CF.sub.3                                                                             CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR137##      CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR138##      CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR139##      CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR140##      CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 CH.sub.3                                                                             Cl   CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 CF.sub.3                                                                             Cl   CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      Cl   CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    Cl   CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   Cl   CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   Cl   CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR141##      Cl   CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        Cl   CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   Cl   CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 Cl   CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 Cl   CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  Cl   CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR142##      Cl   CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR143##      Cl   CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR144##      Cl   CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 CH.sub.3                                                                             F    CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 CF.sub.3                                                                             F    CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      F    CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    F    CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   F    CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   F    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR145##      F    CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        F    CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   F    CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 F    CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 F    CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  F    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR146##      F    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR147##      F    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR148##      F    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR149##      CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR150##      CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR151##      CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR152##      CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR153##      CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR154##      CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR155##      CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR156##      CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR157##      CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR158##      CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR159##      CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR160##      CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR161##      CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR162##      CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR163##      CH.sub.3                                                                            CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR164##      Cl   CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR165##      Cl   CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR166##      Cl   CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR167##      Cl   CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR168##      Cl   CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR169##      Cl   CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR170##      Cl   CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR171##      Cl   CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR172##      Cl   CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR173##      Cl   CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR174##      Cl   CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR175##      Cl   CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR176##      Cl   CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR177##      Cl   CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR178##      Cl   CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR179##      F    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR180##      F    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR181##      F    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR182##      F    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR183##      F    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR184##      F    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR185##      F    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR186##      F    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR187##      F    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR188##      F    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR189##      F    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR190##      F    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR191##      F    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR192##      F    CF.sub.3                                                                            CH.sub.3                                        F                                                                                   ##STR193##      F    CF.sub.3                                                                            CH.sub.3                                        F   NHSO.sub.2 CH.sub.3                                                                             H    CF.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 CF.sub.3                                                                             H    CF.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    CF.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    H    CF.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    CF.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   H    CF.sub.3                                                                            NH.sub.2                                        F                                                                                   ##STR194##      H    CF.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        H    CF.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   H    CF.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 H    CF.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 H    CF.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  H    CF.sub.3                                                                            NH.sub.2                                        F                                                                                   ##STR195##      H    CF.sub.3                                                                            NH.sub.2                                        F                                                                                   ##STR196##      H    CF.sub.3                                                                            NH.sub.2                                        F                                                                                   ##STR197##      H    CF.sub.3                                                                            NH.sub.2                                        F                                                                                   ##STR198##      H    CF.sub.3                                                                            NH.sub.2                                        F                                                                                   ##STR199##      H    CF.sub.3                                                                            NH.sub.2                                        F                                                                                   ##STR200##      H    CF.sub.3                                                                            NH.sub.2                                        F                                                                                   ##STR201##      H    CF.sub.3                                                                            NH.sub.2                                        F                                                                                   ##STR202##      H    CF.sub.3                                                                            NH.sub.2                                        F                                                                                   ##STR203##      H    CF.sub.3                                                                            NH.sub.2                                        F                                                                                   ##STR204##      H    CF.sub.3                                                                            NH.sub.2                                        F                                                                                   ##STR205##      H    CF.sub.3                                                                            NH.sub.2                                        F                                                                                   ##STR206##      H    CF.sub.3                                                                            NH.sub.2                                        F                                                                                   ##STR207##      H    CF.sub.3                                                                            NH.sub.2                                        F                                                                                   ##STR208##      H    CF.sub.3                                                                            NH.sub.2                                        F                                                                                   ##STR209##      H    CF.sub.3                                                                            NH.sub.2                                        F                                                                                   ##STR210##      H    CF.sub.3                                                                            NH.sub.2                                        F                                                                                   ##STR211##      H    CF.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 CH.sub.3                                                                             CH.sub.3                                                                            CF.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 CF.sub.3                                                                             CH.sub.3                                                                            CF.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      CH.sub.3                                                                            CF.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    CH.sub.3                                                                            CF.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   CH.sub.3                                                                            CF.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   CH.sub.3                                                                            CF.sub.3                                                                            NH.sub.2                                        F                                                                                   ##STR212##      CH.sub.3                                                                            CF.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        CH.sub.3                                                                            CF.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   CH.sub.3                                                                            CF.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 CH.sub.3                                                                            CF.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 CH.sub.3                                                                            CF.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  CH.sub.3                                                                            CF.sub.3                                                                            NH.sub.2                                        F                                                                                   ##STR213##      CH.sub.3                                                                            CF.sub.3                                                                            NH.sub.2                                        F                                                                                   ##STR214##      CH.sub.3                                                                            CF.sub.3                                                                            NH.sub.2                                        F                                                                                   ##STR215##      CH.sub.3                                                                            CF.sub.3                                                                            NH.sub.2                                        F   NHSO.sub.2 CH.sub.3                                                                             H    CF.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 CF.sub.3                                                                             H    CF.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    CF.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    H    CF.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    CF.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   H    CF.sub.3                                                                            CHF.sub.2                                       F                                                                                   ##STR216##      H    CF.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        H    CF.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   H    CF.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 H    CF.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 H    CF.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  H    CF.sub.3                                                                            CHF.sub.2                                       F                                                                                   ##STR217##      H    CF.sub.3                                                                            CHF.sub.2                                       F                                                                                   ##STR218##      H    CF.sub.3                                                                            CHF.sub.2                                       F                                                                                   ##STR219##      H    CF.sub.3                                                                            CHF.sub.2                                       F                                                                                   ##STR220##      H    CF.sub.3                                                                            CHF.sub.2                                       F                                                                                   ##STR221##      H    CF.sub.3                                                                            CHF.sub.2                                       F                                                                                   ##STR222##      H    CF.sub.3                                                                            CHF.sub.2                                       F                                                                                   ##STR223##      H    CF.sub.3                                                                            CHF.sub.2                                       F                                                                                   ##STR224##      H    CF.sub.3                                                                            CHF.sub.2                                       F                                                                                   ##STR225##      H    CF.sub.3                                                                            CHF.sub.2                                       F                                                                                   ##STR226##      H    CF.sub.3                                                                            CHF.sub.2                                       F                                                                                   ##STR227##      H    CF.sub.3                                                                            CHF.sub.2                                       F                                                                                   ##STR228##      H    CF.sub.3                                                                            CHF.sub.2                                       F                                                                                   ##STR229##      H    CF.sub.3                                                                            CHF.sub.2                                       F                                                                                   ##STR230##      H    CF.sub.3                                                                            CHF.sub.2                                       F                                                                                   ##STR231##      H    CF.sub.3                                                                            CHF.sub.2                                       F                                                                                   ##STR232##      H    CF.sub.3                                                                            CHF.sub.2                                       F                                                                                   ##STR233##      H    CF.sub.3                                                                            CHF.sub.2                                       F                                                                                   ##STR234##      H    CF.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 CH.sub.3                                                                             CH.sub.3                                                                            CF.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 CF.sub.3                                                                             CH.sub.3                                                                            CF.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      CH.sub.3                                                                            CF.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    CH.sub.3                                                                            CF.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   CH.sub.3                                                                            CF.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   CH.sub.3                                                                            CF.sub.3                                                                            CHF.sub.2                                       F                                                                                   ##STR235##      CH.sub.3                                                                            CF.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        CH.sub.3                                                                            CF.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   CH.sub.3                                                                            CF.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 CH.sub.3                                                                            CF.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 CH.sub.3                                                                            CF.sub.3                                                                            CHF.sub.2                                       F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  CH.sub.3                                                                            CF.sub.3                                                                            CHF.sub.2                                       F                                                                                   ##STR236##      CH.sub.3                                                                            CF.sub.3                                                                            CHF.sub.2                                       F                                                                                   ##STR237##      CH.sub.3                                                                            CF.sub.3                                                                            CHF.sub.2                                       F                                                                                   ##STR238##      CH.sub.3                                                                            CF.sub.3                                                                            CHF.sub.2                                       H   NHSO.sub.2 CH.sub.3                                                                             H    CHF.sub.2                                                                           CH.sub.3                                        H   NHSO.sub.2 CF.sub.3                                                                             H    CHF.sub.2                                                                           CH.sub.3                                        H   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    CHF.sub.2                                                                           CH.sub.3                                        H   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    H    CHF.sub.2                                                                           CH.sub.3                                        H   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    CHF.sub.2                                                                           CH.sub.3                                        H   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR239##      H    CHF.sub.2                                                                           CH.sub.3                                        H   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        H    CHF.sub.2                                                                           CH.sub.3                                        H   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   H    CHF.sub.2                                                                           CH.sub.3                                        H   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 H    CHF.sub.2                                                                           CH.sub.3                                        H   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 H    CHF.sub.2                                                                           CH.sub.3                                        H   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR240##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR241##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR242##      H    CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 CH.sub.3                                                                             H    CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 CF.sub.3                                                                             H    CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    H    CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR243##      H    CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        H    CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   H    CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 H    CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 H    CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR244##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR245##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR246##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR247##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR248##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR249##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR250##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR251##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR252##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR253##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR254##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR255##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR256##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR257##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR258##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR259##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR260##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR261##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR262##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR263##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR264##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR265##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR266##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR267##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR268##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR269##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR270##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR271##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR272##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR273##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR274##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR275##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR276##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR277##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR278##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR279##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR280##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR281##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR282##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR283##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR284##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR285##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR286##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR287##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR288##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR289##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR290##      H    CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR291##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR292##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR293##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR294##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR295##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR296##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR297##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR298##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR299##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR300##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR301##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR302##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR303##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR304##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR305##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR306##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR307##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR308##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR309##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR310##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR311##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR312##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR313##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR314##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR315##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR316##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR317##      H    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR318##      H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 F                                                                                   ##STR319##      H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 F                                                                                   ##STR320##      H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 F                                                                                   ##STR321##      H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 F                                                                                   ##STR322##      H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 F                                                                                   ##STR323##      H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 F                                                                                   ##STR324##      H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 F                                                                                   ##STR325##      H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 F                                                                                   ##STR326##      H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 F                                                                                   ##STR327##      H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 F                                                                                   ##STR328##      H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 F                                                                                   ##STR329##      H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 F                                                                                   ##STR330##      H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 F                                                                                   ##STR331##      H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 F                                                                                   ##STR332##      H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 H   NHSO.sub.2 CH.sub.3                                                                             H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 H   NHSO.sub.2 CF.sub.3                                                                             H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 H   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 H   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 H   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 H   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 H                                                                                   ##STR333##      H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 H   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 H   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 H   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 H   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 H   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 H                                                                                   ##STR334##      H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 H                                                                                   ##STR335##      H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 H                                                                                   ##STR336##      H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 F   NHSO.sub.2 CH.sub.3                                                                             H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 F   NHSO.sub.2 CF.sub.3                                                                             H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 F                                                                                   ##STR337##      H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 F                                                                                   ##STR338##      H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 F                                                                                   ##STR339##      H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 F                                                                                   ##STR340##      H    CHF.sub.2                                                                           C.sub.2 H.sub.5                                 H   NHSO.sub.2 CH.sub.3                                                                             CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        H   NHSO.sub.2 CF.sub.3                                                                             CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        H   NHSO.sub.2 C.sub.2 H.sub.5                                                                      CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        H   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        H   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        H   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR341##      CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        H   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        H   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        H   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        H   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        H   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR342##      CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR343##      CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        H                                                                                   ##STR344##      CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 CH.sub.3                                                                             CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 CF.sub.3                                                                             CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR345##      CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR346##      CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR347##      CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR348##      CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 CH.sub.3                                                                             Cl   CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 CF.sub.3                                                                             Cl   CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      Cl   CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    Cl   CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   Cl   CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   Cl   CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR349##      Cl   CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        Cl   CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   Cl   CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 Cl   CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 Cl   CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  Cl   CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR350##      Cl   CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR351##      Cl   CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR352##      Cl   CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 CH.sub.3                                                                             F    CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 CF.sub.3                                                                             F    CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      F    CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    F    CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   F    CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   F    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR353##      F    CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        F    CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   F    CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 F    CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 F    CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  F    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR354##      F    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR355##      F    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR356##      F    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR357##      CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR358##      CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR359##      CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR360##      CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR361##      CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR362##      CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR363##      CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR364##      CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR365##      CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR366##      CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR367##      CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR368##      CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR369##      CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR370##      CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR371##      CH.sub.3                                                                            CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR372##      Cl   CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR373##      Cl   CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR374##      Cl   CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR375##      Cl   CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR376##      Cl   CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR377##      Cl   CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR378##      Cl   CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR379##      Cl   CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR380##      Cl   CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR381##      Cl   CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR382##      Cl   CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR383##      Cl   CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR384##      Cl   CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR385##      Cl   CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR386##      Cl   CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR387##      F    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR388##      F    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR389##      F    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR390##      F    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR391##      F    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR392##      F    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR393##      F    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR394##      F    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR395##      F    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR396##      F    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR397##      F    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR398##      F    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR399##      F    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR400##      F    CHF.sub.2                                                                           CH.sub.3                                        F                                                                                   ##STR401##      F    CHF.sub.2                                                                           CH.sub.3                                        F   NHSO.sub.2 CH.sub.3                                                                             H    CHF.sub.2                                                                           NH.sub.2                                        F   NHSO.sub.2 CF.sub.3                                                                             H    CHF.sub.2                                                                           NH.sub.2                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    CHF.sub.2                                                                           NH.sub.2                                        F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    H    CHF.sub.2                                                                           NH.sub.2                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    CHF.sub.2                                                                           NH.sub.2                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   H    CHF.sub.2                                                                           NH.sub.2                                        F                                                                                   ##STR402##      H    CHF.sub.2                                                                           NH.sub.2                                        F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        H    CHF.sub.2                                                                           NH.sub.2                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   H    CHF.sub.2                                                                           NH.sub.2                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 H    CHF.sub.2                                                                           NH.sub.2                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 H    CHF.sub.2                                                                           NH.sub.2                                        F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  H    CHF.sub.2                                                                           NH.sub.2                                        F                                                                                   ##STR403##      H    CHF.sub.2                                                                           NH.sub.2                                        F                                                                                   ##STR404##      H    CHF.sub.2                                                                           NH.sub.2                                        F                                                                                   ##STR405##      H    CHF.sub.2                                                                           NH.sub.2                                        F                                                                                   ##STR406##      H    CHF.sub.2                                                                           NH.sub.2                                        F                                                                                   ##STR407##      H    CHF.sub.2                                                                           NH.sub.2                                        F                                                                                   ##STR408##      H    CHF.sub.2                                                                           NH.sub.2                                        F                                                                                   ##STR409##      H    CHF.sub.2                                                                           NH.sub.2                                        F                                                                                   ##STR410##      H    CHF.sub.2                                                                           NH.sub.2                                        F                                                                                   ##STR411##      H    CHF.sub.2                                                                           NH.sub.2                                        F                                                                                   ##STR412##      H    CHF.sub.2                                                                           NH.sub.2                                        F                                                                                   ##STR413##      H    CHF.sub.2                                                                           NH.sub.2                                        F                                                                                   ##STR414##      H    CHF.sub.2                                                                           NH.sub.2                                        F                                                                                   ##STR415##      H    CHF.sub.2                                                                           NH.sub.2                                        F                                                                                   ##STR416##      H    CHF.sub.2                                                                           NH.sub.2                                        F                                                                                   ##STR417##      H    CHF.sub.2                                                                           NH.sub.2                                        F                                                                                   ##STR418##      H    CHF.sub.2                                                                           NH.sub.2                                        F                                                                                   ##STR419##      H    CHF.sub.2                                                                           NH.sub.2                                        F                                                                                   ##STR420##      H    CHF.sub.2                                                                           NH.sub.2                                        F   NHSO.sub.2 CH.sub.3                                                                             CH.sub.3                                                                            CHF.sub.2                                                                           NH.sub.2                                        F   NHSO.sub.2 CF.sub.3                                                                             CH.sub.3                                                                            CHF.sub.2                                                                           NH.sub.2                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      CH.sub.3                                                                            CHF.sub.2                                                                           NH.sub.2                                        F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    CH.sub.3                                                                            CHF.sub.2                                                                           NH.sub.2                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   CH.sub.3                                                                            CHF.sub.2                                                                           NH.sub.2                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   CH.sub.3                                                                            CHF.sub.2                                                                           NH.sub.2                                        F                                                                                   ##STR421##      CH.sub.3                                                                            CHF.sub.2                                                                           NH.sub.2                                        F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        CH.sub.3                                                                            CHF.sub.2                                                                           NH.sub.2                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   CH.sub.3                                                                            CHF.sub.2                                                                           NH.sub.2                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 CH.sub.3                                                                            CHF.sub.2                                                                           NH.sub.2                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 CH.sub.3                                                                            CHF.sub.2                                                                           NH.sub.2                                        F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  CH.sub.3                                                                            CHF.sub.2                                                                           NH.sub.2                                        F                                                                                   ##STR422##      CH.sub.3                                                                            CHF.sub.2                                                                           NH.sub.2                                        F                                                                                   ##STR423##      CH.sub.3                                                                            CHF.sub.2                                                                           NH.sub.2                                        F                                                                                   ##STR424##      CH.sub.3                                                                            CHF.sub.2                                                                           NH.sub.2                                        F   NHSO.sub.2 CH.sub.3                                                                             H    CHF.sub.2                                                                           CHF.sub.2                                       F   NHSO.sub.2 CF.sub.3                                                                             H    CHF.sub.2                                                                           CHF.sub.2                                       F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    CHF.sub.2                                                                           CHF.sub.2                                       F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    H    CHF.sub.2                                                                           CHF.sub.2                                       F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    CHF.sub.2                                                                           CHF.sub.2                                       F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   H    CHF.sub.2                                                                           CHF.sub.2                                       F                                                                                   ##STR425##      H    CHF.sub.2                                                                           CHF.sub.2                                       F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        H    CHF.sub.2                                                                           CHF.sub.2                                       F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   H    CHF.sub.2                                                                           CHF.sub.2                                       F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 H    CHF.sub.2                                                                           CHF.sub.2                                       F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 H    CHF.sub.2                                                                           CHF.sub.2                                       F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  H    CHF.sub.2                                                                           CHF.sub.2                                       F                                                                                   ##STR426##      H    CHF.sub.2                                                                           CHF.sub.2                                       F                                                                                   ##STR427##      H    CHF.sub.2                                                                           CHF.sub.2                                       F                                                                                   ##STR428##      H    CHF.sub.2                                                                           CHF.sub.2                                       F                                                                                   ##STR429##      H    CHF.sub.2                                                                           CHF.sub.2                                       F                                                                                   ##STR430##      H    CHF.sub.2                                                                           CHF.sub.2                                       F                                                                                   ##STR431##      H    CHF.sub.2                                                                           CHF.sub.2                                       F                                                                                   ##STR432##      H    CHF.sub.2                                                                           CHF.sub.2                                       F                                                                                   ##STR433##      H    CHF.sub.2                                                                           CHF.sub.2                                       F                                                                                   ##STR434##      H    CHF.sub.2                                                                           CHF.sub.2                                       F                                                                                   ##STR435##      H    CHF.sub.2                                                                           CHF.sub.2                                       F                                                                                   ##STR436##      H    CHF.sub.2                                                                           CHF.sub.2                                       F                                                                                   ##STR437##      H    CHF.sub.2                                                                           CHF.sub.2                                       F                                                                                   ##STR438##      H    CHF.sub.2                                                                           CHF.sub.2                                       F                                                                                   ##STR439##      H    CHF.sub.2                                                                           CHF.sub.2                                       F                                                                                   ##STR440##      H    CHF.sub.2                                                                           CHF.sub.2                                       F                                                                                   ##STR441##      H    CHF.sub.2                                                                           CHF.sub.2                                       F                                                                                   ##STR442##      H    CHF.sub.2                                                                           CHF.sub.2                                       F                                                                                   ##STR443##      H    CHF.sub.2                                                                           CHF.sub.2                                       F   NHSO.sub.2 CH.sub.3                                                                             CH.sub.3                                                                            CHF.sub.2                                                                           CHF.sub.2                                       F   NHSO.sub.2 CF.sub.3                                                                             CH.sub.3                                                                            CHF.sub.2                                                                           CHF.sub.2                                       F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      CH.sub.3                                                                            CHF.sub.2                                                                           CHF.sub.2                                       F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    CH.sub.3                                                                            CHF.sub.2                                                                           CHF.sub.2                                       F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   CH.sub.3                                                                            CHF.sub.2                                                                           CHF.sub.2                                       F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   CH.sub.3                                                                            CHF.sub.2                                                                           CHF.sub.2                                       F                                                                                   ##STR444##      CH.sub.3                                                                            CHF.sub.2                                                                           CHF.sub.2                                       F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        CH.sub.3                                                                            CHF.sub.2                                                                           CHF.sub.2                                       F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   CH.sub.3                                                                            CHF.sub.2                                                                           CHF.sub.2                                       F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 CH.sub.3                                                                            CHF.sub.2                                                                           CHF.sub.2                                       F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 CH.sub.3                                                                            CHF.sub.2                                                                           CHF.sub.2                                       F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  CH.sub.3                                                                            CHF.sub.2                                                                           CHF.sub.2                                       F                                                                                   ##STR445##      CH.sub.3                                                                            CHF.sub.2                                                                           CHF.sub.2                                       F                                                                                   ##STR446##      CH.sub.3                                                                            CHF.sub.2                                                                           CHF.sub.2                                       H   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR447##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR448##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR449##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR450##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 CH.sub.3                                                                             H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 CF.sub.3                                                                             H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR451##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR452##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR453##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR454##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR455##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR456##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR457##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR458##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR459##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR460##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR461##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR462##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR463##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR464##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR465##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR466##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR467##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR468##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR469##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR470##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR471##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR472##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR473##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR474##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR475##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR476##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR477##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR478##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR479##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR480##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR481##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR482##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR483##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR484##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR485##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR486##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR487##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR488##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR489##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR490##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR491##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR492##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR493##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR494##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR495##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR496##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR497##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR498##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR499##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR500##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR501##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR502##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR503##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR504##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR505##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR506##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR507##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR508##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR509##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR510##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR511##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR512##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR513##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR514##      H    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR515##      H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 F                                                                                   ##STR516##      H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 F                                                                                   ##STR517##      H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 F                                                                                   ##STR518##      H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 F                                                                                   ##STR519##      H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 F                                                                                   ##STR520##      H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 F                                                                                   ##STR521##      H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 F                                                                                   ##STR522##      H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 F                                                                                   ##STR523##      H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 F                                                                                   ##STR524##      H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 F                                                                                   ##STR525##      H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 F                                                                                   ##STR526##      H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 F                                                                                   ##STR527##      H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 F                                                                                   ##STR528##      H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 F                                                                                   ##STR529##      H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 H   NHSO.sub.2 CH.sub.3                                                                             H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 H   NHSO.sub.2 CF.sub.3                                                                             H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 H   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 H   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 H   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 H   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 H                                                                                   ##STR530##      H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 H   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 H   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 H   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 H   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 H   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 H                                                                                   ##STR531##      H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 H                                                                                   ##STR532##      H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 H                                                                                   ##STR533##      H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 F   NHSO.sub.2 CH.sub.3                                                                             H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 F   NHSO.sub.2 CF.sub.3                                                                             H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 F                                                                                   ##STR534##      H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 F                                                                                   ##STR535##      H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 F                                                                                   ##STR536##      H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 F                                                                                   ##STR537##      H    C.sub.2 F.sub.5                                                                     C.sub.2 H.sub.5                                 H   NHSO.sub.2 CH.sub.3                                                                             CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        H   NHSO.sub.2 CF.sub.3                                                                             CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        H   NHSO.sub.2 C.sub.2 H.sub.5                                                                      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        H   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        H   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        H   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR538##      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        H   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        H   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        H   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        H   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        H   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR539##      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR540##      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        H                                                                                   ##STR541##      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 CH.sub.3                                                                             CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 CF.sub.3                                                                             CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR542##      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR543##      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR544##      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR545##      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 CH.sub.3                                                                             Cl   C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 CF.sub.3                                                                             Cl   C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      Cl   C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    Cl   C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   Cl   C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   Cl   C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR546##      Cl   C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        Cl   C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   Cl   C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 Cl   C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 Cl   C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  Cl   C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR547##      Cl   C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR548##      Cl   C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR549##      Cl   C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 CH.sub.3                                                                             F    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 CF.sub.3                                                                             F    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      F    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    F    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   F    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   F    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR550##      F    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        F    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   F    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 F    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 F    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  F    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR551##      F    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR552##      F    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR553##      F    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR554##      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR555##      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR556##      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR557##      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR558##      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR559##      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR560##      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR561##      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR562##      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR563##      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR564##      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR565##      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR566##      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR567##      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR568##      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR569##      Cl   C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR570##      Cl   C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR571##      Cl   C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR572##      Cl   C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR573##      Cl   C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR574##      Cl   C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR575##      Cl   C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR576##      Cl   C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR577##      Cl   C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR578##      Cl   C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR579##      Cl   C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR580##      Cl   C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR581##      Cl   C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR582##      Cl   C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR583##      Cl   C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR584##      F    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR585##      F    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR586##      F    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR587##      F    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR588##      F    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR589##      F    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR590##      F    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR591##      F    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR592##      F    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR593##      F    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR594##      F    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR595##      F    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR596##      F    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR597##      F    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F                                                                                   ##STR598##      F    C.sub.2 F.sub.5                                                                     CH.sub.3                                        F   NHSO.sub.2 CH.sub.3                                                                             H    C.sub.2 F.sub.5                                                                     NH.sub.2                                        F   NHSO.sub.2 CF.sub.3                                                                             H    C.sub.2 F.sub.5                                                                     NH.sub.2                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    C.sub.2 F.sub.5                                                                     NH.sub.2                                        F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    H    C.sub.2 F.sub.5                                                                     NH.sub.2                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    C.sub.2 F.sub.5                                                                     NH.sub.2                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   H    C.sub.2 F.sub.5                                                                     NH.sub.2                                        F                                                                                   ##STR599##      H    C.sub.2 F.sub.5                                                                     NH.sub.2                                        F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        H    C.sub.2 F.sub.5                                                                     NH.sub.2                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   H    C.sub.2 F.sub.5                                                                     NH.sub.2                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 H    C.sub.2 F.sub.5                                                                     NH.sub.2                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 H    C.sub.2 F.sub.5                                                                     NH.sub.2                                        F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  H    C.sub.2 F.sub.5                                                                     NH.sub.2                                        F                                                                                   ##STR600##      H    C.sub.2 F.sub.5                                                                     NH.sub.2                                        F                                                                                   ##STR601##      H    C.sub.2 F.sub.5                                                                     NH.sub.2                                        F                                                                                   ##STR602##      H    C.sub.2 F.sub.5                                                                     NH.sub.2                                        F                                                                                   ##STR603##      H    C.sub.2 F.sub.5                                                                     NH.sub.2                                        F                                                                                   ##STR604##      H    C.sub.2 F.sub.5                                                                     NH.sub.2                                        F                                                                                   ##STR605##      H    C.sub.2 F.sub.5                                                                     NH.sub.2                                        F                                                                                   ##STR606##      H    C.sub.2 F.sub.5                                                                     NH.sub.2                                        F                                                                                   ##STR607##      H    C.sub.2 F.sub.5                                                                     NH.sub.2                                        F                                                                                   ##STR608##      H    C.sub.2 F.sub.5                                                                     NH.sub.2                                        F                                                                                   ##STR609##      H    C.sub.2 F.sub.5                                                                     NH.sub.2                                        F                                                                                   ##STR610##      H    C.sub.2 F.sub.5                                                                     NH.sub.2                                        F                                                                                   ##STR611##      H    C.sub.2 F.sub.5                                                                     NH.sub.2                                        F                                                                                   ##STR612##      H    C.sub.2 F.sub.5                                                                     NH.sub.2                                        F                                                                                   ##STR613##      H    C.sub.2 F.sub.5                                                                     NH.sub.2                                        F                                                                                   ##STR614##      H    C.sub.2 F.sub.5                                                                     NH.sub.2                                        F                                                                                   ##STR615##      H    C.sub.2 F.sub.5                                                                     NH.sub.2                                        F                                                                                   ##STR616##      H    C.sub.2 F.sub.5                                                                     NH.sub.2                                        F                                                                                   ##STR617##      H    C.sub.2 F.sub.5                                                                     NH.sub.2                                        F   NHSO.sub.2 CH.sub.3                                                                             CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     NH.sub.2                                        F   NHSO.sub.2 CF.sub.3                                                                             CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     NH.sub.2                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     NH.sub.2                                        F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     NH.sub.2                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     NH.sub.2                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     NH.sub.2                                        F                                                                                   ##STR618##      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     NH.sub.2                                        F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     NH.sub.2                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     NH.sub.2                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     NH.sub.2                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     NH.sub.2                                        F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     NH.sub.2                                        F                                                                                   ##STR619##      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     NH.sub.2                                        F                                                                                   ##STR620##      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     NH.sub.2                                        F                                                                                   ##STR621##      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     NH.sub.2                                        F   NHSO.sub.2 CH.sub.3                                                                             H    C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F   NHSO.sub.2 CF.sub.3                                                                             H    C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    H    C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   H    C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F                                                                                   ##STR622##      H    C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        H    C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   H    C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 H    C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 H    C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  H    C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F                                                                                   ##STR623##      H    C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F                                                                                   ##STR624##      H    C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F                                                                                   ##STR625##      H    C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F                                                                                   ##STR626##      H    C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F                                                                                   ##STR627##      H    C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F                                                                                   ##STR628##      H    C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F                                                                                   ##STR629##      H    C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F                                                                                   ##STR630##      H    C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F                                                                                   ##STR631##      H    C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F                                                                                   ##STR632##      H    C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F                                                                                   ##STR633##      H    C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F                                                                                   ##STR634##      H    C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F                                                                                   ##STR635##      H    C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F                                                                                   ##STR636##      H    C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F                                                                                   ##STR637##      H    C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F                                                                                   ##STR638##      H    C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F                                                                                   ##STR639##      H    C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F                                                                                   ##STR640##      H    C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F   NHSO.sub.2 CH.sub.3                                                                             CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F   NHSO.sub.2 CF.sub.3                                                                             CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F                                                                                   ##STR641##      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F                                                                                   ##STR642##      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F                                                                                   ##STR643##      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CHF.sub.2                                       F                                                                                   ##STR644##      CH.sub.3                                                                            C.sub.2 F.sub.5                                                                     CHF.sub.2                                       H   NHSO.sub.2 CH.sub.3                                                                             H    CF.sub.2 Cl                                                                         CH.sub.3                                        H   NHSO.sub.2 CF.sub.3                                                                             H    CF.sub.2 Cl                                                                         CH.sub.3                                        H   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    H    CF.sub.2 Cl                                                                         CH.sub.3                                        H   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    CF.sub.2 Cl                                                                         CH.sub.3                                        H   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR645##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 H                                                         H    CF.sub.2 Cl                                                                         CH.sub.3                                        H   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   H    CF.sub.2 Cl                                                                         CH.sub.3                                        H   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 H    CF.sub.2 Cl                                                                         CH.sub.3                                        H   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 H    CF.sub.2 Cl                                                                         CH.sub.3                                        H   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR646##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR647##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR648##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 CH.sub.3                                                                             H    CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 CF.sub.3                                                                             H    CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    H    CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR649##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        H    CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   H    CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 H    CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 H    CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR650##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR651##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR652##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR653##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR654##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR655##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR656##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR657##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR658##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR659##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR660##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR661##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR662##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR663##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR664##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR665##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR666##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR667##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR668##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR669##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR670##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR671##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR672##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR673##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR674##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR675##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR676##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR677##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR678##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR679##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR680##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR681##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR682##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR683##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR684##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR685##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR686##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR687##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR688##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR689##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR690##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR691##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR692##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR693##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR694##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR695##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR696##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR697##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR698##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR699##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR700##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR701##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR702##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR703##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR704##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR705##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR706##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR707##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR708##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR709##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR710##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR711##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR712##      H    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR713##      H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 F                                                                                   ##STR714##      H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 F                                                                                   ##STR715##      H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 F                                                                                   ##STR716##      H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 F                                                                                   ##STR717##      H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 F                                                                                   ##STR718##      H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 F                                                                                   ##STR719##      H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 F                                                                                   ##STR720##      H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 F                                                                                   ##STR721##      H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 F                                                                                   ##STR722##      H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 F                                                                                   ##STR723##      H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 F                                                                                   ##STR724##      H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 F                                                                                   ##STR725##      H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 F                                                                                   ##STR726##      H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 F                                                                                   ##STR727##      H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 H   NHSO.sub.2 CH.sub.3                                                                             H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 H   NHSO.sub.2 CF.sub.3                                                                             H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 H   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 H   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 H   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 H   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 H                                                                                   ##STR728##      H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 H   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 H   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 H   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 H   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 H   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 H                                                                                   ##STR729##      H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 H                                                                                   ##STR730##      H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 H                                                                                   ##STR731##      H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 F   NHSO.sub.2 CH.sub.3                                                                             H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 F   NHSO.sub.2 CF.sub.3                                                                             H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 F                                                                                   ##STR732##      H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 F                                                                                   ##STR733##      H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 F                                                                                   ##STR734##      H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 F                                                                                   ##STR735##      H    CF.sub.2 Cl                                                                         C.sub.2 H.sub.5                                 H   NHSO.sub.2 CH.sub.3                                                                             CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        H   NHSO.sub.2 CF.sub.3                                                                             CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        H   NHSO.sub.2 C.sub.2 H.sub.5                                                                      CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        H   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        H   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        H   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR736##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        H   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        H   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        H   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        H   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        H   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR737##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR738##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        H                                                                                   ##STR739##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 CH.sub.3                                                                             CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 CF.sub.3                                                                             CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR740##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR741##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR742##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR743##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 CH.sub.3                                                                             Cl   CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 CF.sub.3                                                                             Cl   CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      Cl   CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    Cl   CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   Cl   CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   Cl   CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR744##      Cl   CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        Cl   CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   Cl   CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 Cl   CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 Cl   CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  Cl   CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR745##      Cl   CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR746##      Cl   CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR747##      Cl   CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 CH.sub.3                                                                             F    CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 CF.sub.3                                                                             F    CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      F    CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    F    CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   F    CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   F    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR748##      F    CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        F    CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   F    CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 F    CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 F    CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  F    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR749##      F    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR750##      F    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR751##      F    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR752##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR753##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR754##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR755##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR756##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR757##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR758##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR759##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR760##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR761##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR762##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR763##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR764##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR765##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR766##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR767##      Cl   CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR768##      Cl   CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR769##      Cl   CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR770##      Cl   CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR771##      Cl   CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR772##      Cl   CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR773##      Cl   CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR774##      Cl   CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR775##      Cl   CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR776##      Cl   CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR777##      Cl   CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR778##      Cl   CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR779##      Cl   CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR780##      Cl   CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR781##      Cl   CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR782##      F    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR783##      F    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR784##      F    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR785##      F    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR786##      F    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR787##      F    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR788##      F    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR789##      F    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR790##      F    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR791##      F    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR792##      F    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR793##      F    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR794##      F    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR795##      F    CF.sub.2 Cl                                                                         CH.sub.3                                        F                                                                                   ##STR796##      F    CF.sub.2 Cl                                                                         CH.sub.3                                        F   NHSO.sub.2 CH.sub.3                                                                             H    CF.sub.2 Cl                                                                         NH.sub.2                                        F   NHSO.sub.2 CF.sub.3                                                                             H    CF.sub.2 Cl                                                                         NH.sub.2                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    CF.sub.2 Cl                                                                         NH.sub.2                                        F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    H    CF.sub.2 Cl                                                                         NH.sub.2                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    CF.sub.2 Cl                                                                         NH.sub.2                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   H    CF.sub.2 Cl                                                                         NH.sub.2                                        F                                                                                   ##STR797##      H    CF.sub.2 Cl                                                                         NH.sub.2                                        F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        H    CF.sub.2 Cl                                                                         NH.sub.2                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   H    CF.sub.2 Cl                                                                         NH.sub.2                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 H    CF.sub.2 Cl                                                                         NH.sub.2                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 H    CF.sub.2 Cl                                                                         NH.sub.2                                        F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  H    CF.sub.2 Cl                                                                         NH.sub.2                                        F                                                                                   ##STR798##      H    CF.sub.2 Cl                                                                         NH.sub.2                                        F                                                                                   ##STR799##      H    CF.sub.2 Cl                                                                         NH.sub.2                                        F                                                                                   ##STR800##      H    CF.sub.2 Cl                                                                         NH.sub.2                                        F                                                                                   ##STR801##      H    CF.sub.2 Cl                                                                         NH.sub.2                                        F                                                                                   ##STR802##      H    CF.sub.2 Cl                                                                         NH.sub.2                                        F                                                                                   ##STR803##      H    CF.sub.2 Cl                                                                         NH.sub.2                                        F                                                                                   ##STR804##      H    CF.sub.2 Cl                                                                         NH.sub.2                                        F                                                                                   ##STR805##      H    CF.sub.2 Cl                                                                         NH.sub.2                                        F                                                                                   ##STR806##      H    CF.sub.2 Cl                                                                         NH.sub.2                                        F                                                                                   ##STR807##      H    CF.sub.2 Cl                                                                         NH.sub.2                                        F                                                                                   ##STR808##      H    CF.sub.2 Cl                                                                         NH.sub.2                                        F                                                                                   ##STR809##      H    CF.sub.2 Cl                                                                         NH.sub.2                                        F                                                                                   ##STR810##      H    CF.sub.2 Cl                                                                         NH.sub.2                                        F                                                                                   ##STR811##      H    CF.sub.2 Cl                                                                         NH.sub.2                                        F                                                                                   ##STR812##      H    CF.sub.2 Cl                                                                         NH.sub.2                                        F                                                                                   ##STR813##      H    CF.sub.2 Cl                                                                         NH.sub.2                                        F                                                                                   ##STR814##      H    CF.sub.2 Cl                                                                         NH.sub.2                                        F                                                                                   ##STR815##      H    CF.sub.2 Cl                                                                         NH.sub.2                                        F   NHSO.sub.2 CH.sub.3                                                                             CH.sub.3                                                                            CF.sub.2 Cl                                                                         NH.sub.2                                        F   NHSO.sub.2 CF.sub.3                                                                             CH.sub.3                                                                            CF.sub.2 Cl                                                                         NH.sub.2                                        F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      CH.sub.3                                                                            CF.sub.2 Cl                                                                         NH.sub.2                                        F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    CH.sub.3                                                                            CF.sub.2 Cl                                                                         NH.sub.2                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   CH.sub.3                                                                            CF.sub.2 Cl                                                                         NH.sub.2                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   CH.sub.3                                                                            CF.sub.2 Cl                                                                         NH.sub.2                                        F                                                                                   ##STR816##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         NH.sub.2                                        F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        CH.sub.3                                                                            CF.sub.2 Cl                                                                         NH.sub.2                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   CH.sub.3                                                                            CF.sub.2 Cl                                                                         NH.sub.2                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 CH.sub.3                                                                            CF.sub.2 Cl                                                                         NH.sub.2                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 CH.sub.3                                                                            CF.sub.2 Cl                                                                         NH.sub.2                                        F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  CH.sub.3                                                                            CF.sub.2 Cl                                                                         NH.sub.2                                        F                                                                                   ##STR817##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         NH.sub.2                                        F                                                                                   ##STR818##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         NH.sub.2                                        F                                                                                   ##STR819##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         NH.sub.2                                        F   NHSO.sub.2 CH.sub.3                                                                             H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F   NHSO.sub.2 CF.sub.3                                                                             H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    CH.sub.3                                                                            CF.sub.2 Cl                                                                         NH.sub.2                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   CH.sub.3                                                                            CF.sub.2 Cl                                                                         NH.sub.2                                        F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   CH.sub.3                                                                            CF.sub.2 Cl                                                                         NH.sub.2                                        F                                                                                   ##STR820##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         NH.sub.2                                        F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        CH.sub.3                                                                            CF.sub.2 Cl                                                                         NH.sub.2                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   CH.sub.3                                                                            CF.sub.2 Cl                                                                         NH.sub.2                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 CH.sub.3                                                                            CF.sub.2 Cl                                                                         NH.sub.2                                        F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 CH.sub.3                                                                            CF.sub.2 Cl                                                                         NH.sub.2                                        F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  CH.sub.3                                                                            CF.sub.2 Cl                                                                         NH.sub.2                                        F                                                                                   ##STR821##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         NH.sub.2                                        F                                                                                   ##STR822##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         NH.sub.2                                        F                                                                                   ##STR823##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         NH.sub.2                                        F   NHSO.sub.2 CH.sub.3                                                                             H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F   NHSO.sub.2 CF.sub.3                                                                             H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F                                                                                   ##STR824##      H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F                                                                                   ##STR825##      H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F                                                                                   ##STR826##      H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F                                                                                   ##STR827##      H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F                                                                                   ##STR828##      H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F                                                                                   ##STR829##      H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F                                                                                   ##STR830##      H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F                                                                                   ##STR831##      H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F                                                                                   ##STR832##      H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F                                                                                   ##STR833##      H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F                                                                                   ##STR834##      H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F                                                                                   ##STR835##      H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F                                                                                   ##STR836##      H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F                                                                                   ##STR837##      H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F                                                                                   ##STR838##      H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F                                                                                   ##STR839##      H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F                                                                                   ##STR840##      H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F                                                                                   ##STR841##      H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F                                                                                   ##STR842##      H    CF.sub.2 Cl                                                                         CHF.sub.2                                       F   NHSO.sub.2 CH.sub.3                                                                             CH.sub.3                                                                            CF.sub.2 Cl                                                                         CHF.sub.2                                       F   NHSO.sub.2 CF.sub.3                                                                             CH.sub.3                                                                            CF.sub.2 Cl                                                                         CHF.sub.2                                       F   NHSO.sub.2 C.sub.2 H.sub.5                                                                      CH.sub.3                                                                            CF.sub.2 Cl                                                                         CHF.sub.2                                       F   NHSO.sub.2 CH.sub.2 CF.sub.3                                                                    CH.sub.3                                                                            CF.sub.2 Cl                                                                         CHF.sub.2                                       F   NHSO.sub.2 C.sub.3 H.sub.7 -n                                                                   CH.sub.3                                                                            CF.sub.2 Cl                                                                         CHF.sub.2                                       F   NHSO.sub.2 C.sub.3 H.sub.7 -i                                                                   CH.sub.3                                                                            CF.sub.2 Cl                                                                         CHF.sub.2                                       F                                                                                   ##STR843##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         CHF.sub.2                                       F   NHSO.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        CH.sub.3                                                                            CF.sub.2 Cl                                                                         CHF.sub.2                                       F   NHSO.sub.2 C.sub.4 H.sub.9 -n                                                                   CH.sub.3                                                                            CF.sub.2 Cl                                                                         CHF.sub.2                                       F   NHSO.sub.2 C.sub.4 H.sub.9 -sec                                                                 CH.sub.3                                                                            CF.sub.2 Cl                                                                         CHF.sub.2                                       F   NHSO.sub.2 C.sub.4 H.sub.9 -iso                                                                 CH.sub.3                                                                            CF.sub.2 Cl                                                                         CHF.sub.2                                       F   NHSO.sub.2 C.sub.5 H.sub.10 -n                                                                  CH.sub.3                                                                            CF.sub.2 Cl                                                                         CHF.sub.2                                       F                                                                                   ##STR844##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         CHF.sub.2                                       F                                                                                   ##STR845##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         CHF.sub.2                                       F                                                                                   ##STR846##      CH.sub.3                                                                            CF.sub.2 Cl                                                                         CHF.sub.2                                       __________________________________________________________________________

If, for example, methyl 3-aminocrotonate and 4-cyano-2,5-difluorophenyl isocyanate are used as starting substances, the course of the reaction in process (a) according to the invention can be outlined by the following equation: ##STR847##

If, for example, 1-(3-chloro-4-cyano-phenyl)-3,6-dihydro-2,6-dioxo-4-trifluoromethyl-1(2H) -pyrimidine and methyl bromide are used as starting substances, the course of the reaction in process (b) according to the invention can be outlined by the following equation: ##STR848##

If, for example, 1-(4-cyano-2,5-difluoro-phenyl)-3,6-dihydro-3,4-dimethyl-2,6-dioxo-1(2H)-pyrimidine and ethanesulphonamide are used as starting substances, the course of the reaction in process (c) according to the invention can be outlined by the following equation: ##STR849##

Formula (II) provides a general definition of the amino-alkenoic esters to be used as starting substances in process (a) according to the invention for the preparation of compounds of the formula (I).

In Formula (II) R³ and R⁴, preferably, or in particular, have those meanings which have already been mentioned above in connection with the description of the compounds of the formula (I) according to the invention as being preferred, or particularly preferred, for R³ and R⁴.

R preferably represents C₁ -C₄ -alkyl, phenyl or benzyl, in particular methyl or phenyl.

The starting substances of formula (II) are known and/or can be prepared by known processes (cf. J. Heterocycl. Chem. 9 (1972), 513-522).

Formula (III) provides a general definition of the cyanoaryl isocyanates furthermore to be used as starting substances in process (a) according to the invention.

In Formula (III), R¹ and R² preferably, or in particular, have those meanings which have already been mentioned above in connection with the description of compounds of the formula (I) according to the invention as being preferred, or particularly preferred, for R¹ and R². The cyanoaryl isocyanates of the general formula (III) were hitherto not known from the literature and, being new substances, are the subject of the present application.

The new cyanoaryl isocyanates of the formula (III) are obtained when cyanoarylamines of the general formula (VIII) ##STR850## in which

R¹ and R² have the abovementioned meanings, are reacted with phosgene in the presence of a diluent, such as, for example, chlorobenzene, at temperatures between -20° C. and +150° C. (cf. the preparation examples).

The cyanoarylurethanes optionally to be used as starting materials in process (a) according to the invention are defined in general by the formula (IV). In the formula (IV), R¹ and R² preferably or in particular have those meanings which have already been mentioned above in connection with the description of the compounds of the formula (I) as being preferred or particularly preferable for R¹ and R² ; R preferably represents C₁ -C₄ -alkyl, phenyl or benzyl, in particular methyl or phenyl.

The cyanoarylurethanes of the general formula (IV) are not yet known from the literature; as novel substances, they are the subject of the present application.

The novel cyanoarylurethanes of the formula (IV) are obtained if cyanoarylanines of the general formula (VIII)--above--are reacted with chlorocarbonyl compounds of the general formula (IX)

    RO--CO--Cl                                                 (IX)

in which

R has the abovementioned meaning, optionally in the presence of an acid acceptor, such as, for example, pyridine, and optionally in the presence of a diluent, such as, for example, methylene chloride, at temperatures between 0° C. and 100° C. (cf. preparation examples).

Process (a) according to the invention for the preparation of the new N-cyanoaryl-nitrogen heterocycles of the formula (I) is preferably carried out using diluents. Diluents which are suitable are virtually all inert organic solvents. These preferably include aliphatic and aromatic, optionally halogenated hydrocarbons, such as pentane, hexane, heptane, cyclohexane, petroleum ether, benzine, ligroin, benzene, toluene, xylene, methylene chloride, ethylene chloride, chloroform, tetrachloromethane, chlorobenzene and o-dichlorobenzene, ethers, such as diethyl ether, dibutyl ether, glycol dimethyl ether, diglycol dimethyl ether, tetrahydrofuran and dioxane, ketones, such as acetone, methyl ethyl ketone, methyl isopropyl ketone and methyl isobutyl ketone, esters, such as methyl acetate and ethyl acetate, nitriles, such as, for example, acetonitrile and propionitrile, amides, such as, for example, dimethylformamide, dimethylacetamide and N-methylpyrrolidone, and also dimethyl sulphoxide, tetramethylene sulphone and hexamethylphosphoric triamide.

Process (a) according to the invention is preferably carried out in the presence of a reaction auxiliary. Suitable as reaction auxiliaries are mainly acid acceptors. The following are preferably suitable: alkali metal hydrides and alkaline earth metal hydrides, such as lithium hydride, sodium hydride, potassium hydride and calcium hydride, alkali metal hydroxides and alkaline earth metal hydroxides, such as lithium hydroxide, sodium hydroxide, potassium hydroxide and calcium hydroxide, alkali metal carbonates, alkali metal hydrogen carbonates, alkaline earth metal carbonates and alkaline earth metal hydrogen carbonates, such as sodium carbonate, sodium hydrogen carbonate, potassium carbonate or potassium hydrogen carbonate, and calcium carbonate, alkali metal acetates, such as sodium acetate and potassium acetate, alkali metal alcoholates, such as sodium methylate, sodium ethylate, sodium propylate, sodium isopropylate, sodium butylate, sodium isobutylate, sodium tertbutylate, potassium methylate, potassium ethylate, potassium propylate, potassium isopropylater potassium butylate, potassium isobutylate and potassium tert-butylate, furthermore basic nitrogen compounds, such as trimethylamine, triethylamine, tripropylamine, tributylamine, diisobutylamine, dicyclohexylamine, ethylduisopropylamine, ethyldicyclohexylamine, N,N-dimethylbenzylamine, N,N-dimethyl-aniline, pyridine, 2-methyl-, 3-methyl-, 4-methyl- 2,4-dimethyl-, 2,,6-dimethyl-, 2-ethyl-, 4-ethyl- and 5-ethyl-2-methyl-pyridine, 1,5-diazabicyclo[4,3,0]-non-5-ene (DBN), 1,8-diazabicyclo-[5,4,0]-undec-7-ene (DBU) and 1,4-diazabicyclo-[2,2,2]-octane (DABCO).

When carrying out process (a) according to the invention, the reaction temperatures can be varied within a substantial range. In general the process is carried out at temperatures between -120° C. and +100° C., preferably at temperatures between -70° C. and +80° C.

In general, process (a) according to the invention is carried out under atmospheric pressure. However, it is also possible to carry out the process under elevated or reduced pressure.

To carry out process (a) according to the invention, the starting substances required in each case are generally employed in approximately equimolar amounts. However, it is also possible to use one of the two components employed in each case in a relatively large excess. In general, the reactions are carried out in a suitable diluent in the presence of a reaction auxiliary, and the reaction mixture is stirred for several hours at the temperature required in each case. Working-up in process (a) according to the invention is carried out in each case by customary methods (cf. the preparation examples).

Formulae (IA) and (IB)--with the proviso that R⁵ in these formulae represents hydrogen--provide a general definition of the N-cyanoaryl-nitrogen heterocycles to be used as starting substances in process (b) according to the invention for the preparation of compounds of the formula (I).

In formulae (IA) and (IB), R¹, R², R³ and R⁴ preferably, or in particular, have those meanings which have already been mentioned above in connection with the description of the compounds of the formula (I) according to the invention as being preferred, or particularly preferred, for R¹, R², R³ and R⁴.

The starting substances of the formulae (IA) and (IB) for process (b) are new compounds according to the invention; they can be prepared by process (a) according to the invention.

Formulae (V) and (VI) provide general definitions of the alkylating agents furthermore to be used as starting substances in process (b) according to the invention.

In formulae (V) and (VI), R⁵ preferably, or in particular, has the meaning which has already been mentioned above in connection with the description of the compounds of the formula (I) according to the invention as being preferred, or particularly preferred, for R⁵.

The starting substances of the formulae (V) and (VI) are known chemicals for organic synthesis.

Process (b) according to the invention is preferably carried out using a diluent. Suitable diluents are mainly those which have already been mentioned in the description of the process (a) according to the invention.

Acid acceptors which can be employed in process (b) according to the invention are all acid-binding agents which can conventionally be used for such reactions. The following are preferably suitable: alkali metal hydrides and alkaline earth metal hydrides, such as lithium hydride, sodium hydride, potassium hydride and calcium hydride, alkali metal hydroxides and alkaline earth metal hydroxides, such as lithium hydroxide, sodium hydroxide, potassium hydroxide and calcium hydroxide, alkali metal carbonates, alkali metal hydrogen carbonates, alkaline earth metal carbonates and alkaline earth metal hydrogen carbonates, such as sodium carbonate, sodium hydrogen carbonate, potassium carbonate or potassium hydrogen carbonate, and calcium carbonate, alkali metal acetates, such as sodium acetate and potassium acetate, alkali metal alcoholates, such as sodium methylate, sodium ethylate, sodium propylate, sodium isopropylate, sodium butylate, sodium isobutylate, sodium tert-butylate, potassium methylate, potassium ethylate, potassium propylate, potassium isopropylate, potassium butylate, potassium isobutylate and potassium tert-butylate, furthermore basic nitrogen compounds, such as trimethylamine, triethylamine, tripropylamine, tributylamine, diisobutylamine, dicyclohexylamine, ethyldiisopropylamine, ethyldicyclohexylamine, N,N-dimethylbenzylamine, N,N-dimethyl-aniline, pyridine, 2-methyl-, 3-methyl-, 4-methyl-, 2,4-dimethyl-, 2,6-dimethyl-, 2-ethyl-, 4-ethyl- and 5-ethyl-2-methyl-pyridine, 1,5-diazabicyclo[4,3,0]-non-5-ene (DBN), 1,8-diazabicyclo-[5,4,0]-undec-7-en (DBU) and 1,4-diazabicyclo-[2,2,2]-octane (DABCO).

When carrying out process (b) according to the invention, the reaction temperatures can be varied within a substantial range. In general the process is carried out at temperatures between 0° C. and 120° C., preferably at temperatures between 10° C. and 100° C.

In general, process (b) according to the invention is carried out under atmospheric pressure. However, it is also possible to carry out the process under elevated or reduced pressure.

To carry out process (b) according to the invention, the starting substances required in each case are generally employed in approximately equimolar amounts. However, it is also possible to use one of the two components employed in each case in a relatively large excess. In general, the reactions are carried out in a suitable diluent in the presence of an acid acceptor, and the reaction mixture is stirred for several hours at the temperature required in each case. Working-up in process (b) according to the invention is carried out in each case by customary methods (cf. the preparation examples).

Formula (I)--with the proviso that R² in this formula represents halogen--provides a general definition of the N-cyanoaryl-nitrogen heterocycles to be used as starting substances in process (c) according to the invention for the preparation of compounds of the formula (I).

In formula (I), R¹, R³, R⁴ and Z then preferably, or particularly preferably, have those meanings which have already been mentioned above in connection with the description of the compounds of the formula (I) according to the invention as being preferred, or particularly preferred, for R¹, R³, R⁴ and Z.

The starting substances of the formula (I) for process (c) are new compounds according to the invention; they can be prepared by processes (a) and (b) according to the invention.

Formula (VII) provides a general definition of the amides furthermore to be used as starting substances in process (c) according to the invention.

In formula (VII), A preferably, or in particular, has the meaning which has already been mentioned above in connection with the description of the compounds of the formula (I) according to the invention as being preferred, or particularly preferred, for A.

The starting substances of the formula (VII) are known chemicals for organic synthesis.

Process (c) according to the invention is preferably carried out using a diluent. Suitable diluents are mainly those diluents which have already been mentioned in the description of process (a) according to the invention.

If appropriate, process (c) according to the invention is carried out in the presence of an acid acceptor. Suitable acid acceptors are those which have already been mentioned in the description of the process (b) according to the invention.

When carrying out process (c) according to the invention, the reaction temperatures can be varied within a substantial range. In general, the process is carried out at temperatures between 0° C. and 200° C., preferably at temperatures between 20° C. and 180° C.

In general, process (c) according to the invention is carried out under atmospheric pressure. However, it is also possible to carry out the process under elevated or reduced pressure.

To carry out process (c) according to the invention, the starting substances required in each case are generally employed in approximately equimolar amounts. However, it is also possible to use one of the two components employed in each case in a relatively large excess. In general, the reactions are carried out in a suitable diluent in the presence of an acid acceptor, and the reaction mixture is stirred for several hours at the temperature required in each case. Working-up in process (c) according to the invention is carried out in each case by customary methods (cf. preparation examples).

The active compounds according to the invention can be used as defoliants, desiccants agents for destroying broad-leaved plants and, especially, as weed-killers. By weeds, in the broadest sense, there are to be understood all plants which grow in locations where they are undesired. Whether the substances according to the invention act as total or selective herbicides depends essentially on the amount used.

The active compounds according to the invention can be used, for example, in connection with the following plants:

Dicotyledon weeds of the genera: Sinapis, Lepidium, Galium, Stellaria, Matricaria, Anthemis, Galinsoga, Chenopodium, Urtica, Senecio, Amaranthus, Portulaca, Xanthium, Convolvulus, Ipomoea, Polygonum, Sesbania, Ambrosia, Cirsium, Carduus, Sonchus, Solanum, Rorippa, Rotala, Lindernia, Lamium, Veronica, Abutilon, Emex, Datura, Viola, Galeopsis, Papaver, Centaurea, Trifolium, Ranunculus and Taraxacum.

Dicotyledon cultures of the genera: Gossypium, Glycine, Beta, Daucus, Phaseolus, Pisum, Solanum, Linum, Ipomoea, Vicia, Nicotiana, Lycopersicon, Arachis, Brassica, Lactuca, Cucumis and Cucurbita.

Monocotyledon weeds of the genera: Echinochloa, Setaria, Panicum, Digitaria, Phleum, Poa, Festuca, Eleusine, Brachiaria, Lolium, Bromus, Avena, Cyperus, Sorghum, Agropyron, Cynodon, Monochoria, Fimbristylis, Sagittaria, Eleocharis, Scirpus, Paspalum, Ischaemum, Sphenoclea, Dactyloctenium, Agrostis, Alopecurus and Apera.

Monocotyledon cultures of the genera: Oryza, Zea, Triticum, Hordeum, Avena, Secale, Sorghum, Panicum, Saccharum, Ananas, Asparagus and Allium.

However, the use of the active compounds according to the invention is in no way restricted to these genera, but also extends in the same manner to other plants. The compounds are suitable, depending on the concentration, for the total combating of weeds, for example on industrial terrain and rail tracks, and on paths and squares with or without tree plantings. Equally, the compounds can be employed for combating weeds in perennial cultures, for example afforestations, decorative tree plantings, orchards, vineyards, citrus groves, nut orchards, banana plantations, coffee plantations, tea plantations, rubber plantations, oil palm plantations, cocoa plantations, soft fruit plantings and hopfields, in lawns, turf and pasture-land, and for the selective combating of weeds in annual cultures.

The compounds of the formula (I) according to the invention--inclusively those disclaimed by disclaimer--are particularly suitable for selectively combating dicotyledonous weeds in monocotyledon and dicotyledon cultures, such as, for example, in wheat, maize and soya beans, both in the pre-emergence method and in the post-emergence method, although the individual compounds including those disclaimed by disclaimer, have selective activity in cultures, such as, for example, in wheat, corn and sova beans.

The active compounds can be converted into the customary formulations, such as solutions, emulsions, wettable powders, suspensions, powders, dusting agents, pastes, soluble powders, granules, suspension-emulsion concentrates, natural and synthetic materials impregnated with active compound, and very fine capsules in polymeric substances.

These formulations are produced in a known manner, for example by mixing the active compounds with extenders, that is liquid solvents and/or solid carriers, optionally with the use of surface-active agents, that is emulsifying agents and/or dispersing agents and/or foam-forming agents.

In the case of the use of water as an extender, organic solvents can, for example, also be used as auxiliary solvents. As liquid solvents, there are suitable in the main: aromatics, such as xylene, toluene or alkylnaphthalenes, chlorinated aromatics and chlorinated aliphatic hydrocarbons, such as chlorobenzenes, chloroethylenes or methylene chloride, aliphatic hydrocarbons, such as cyclohexane or paraffins, for example petroleum fractions, mineral and vegetable oils, alcohols, such as butanol or glycol as well as their ethers and esters, ketones, such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone, strongly polar solvents, such as dimethylformamide and dimethyl sulphoxide, as well as water.

As solid carriers there are suitable: for example ammonium salts and ground natural minerals, such as kaolins, clays, talc, chalk, quartz, attapulgite, montmorillonite or diatomaceous earth, and ground synthetic minerals, such as highly disperse silica, alumina and silicates, as solid carriers for granules there are suitable: for example crushed and fractionated natural rocks such as calcite, marble, pumice, sepiolite and dolomite, as well as synthetic granules of inorganic and organic meals, and granules of organic material such as sawdust, coconut shells, maize cobs and tobacco stalks; as emulsifying and/or foam-forming agents there are suitable: for example non-ionic and anionic emulsifiers, such as polyoxyethylene fatty acid esters, polyoxyethylene fatty alcohol ethers, for example alkylaryl polyglycol ethers, alkylsulphonates, alkyl sulphates, arylsulphonates as well as albumen hydrolysis products; as dispersing agents there are suitable: for example lignin-sulphite waste liquors and methylcellulose.

Adhesives such as carboxymethylcellulose and natural and synthetic polymers in the form of powders, granules or latexes, such as gum arabic, polyvinyl alcohol and polyvinyl acetate, as well as natural phospholipids, such as cephalins and lecithins, and synthetic phospholipids, can be used in the formulations. Further additives can be mineral and vegetable oils.

It is possible to use colorants such as inorganic pigments, for example iron oxide, titanium oxide and Prussian Blue, and organic dyestuffs, such as alizarin dyestuffs, azo dyestuffs and metal phthalocyanine dye-stuffs, and trace nutrients such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc.

The formulations in general contain between 0.1 and 95 per cent by weight of active compound, preferably between 0.5 and 90%.

For combating weeds, the active compounds according to the invention, as such or in their formulations, can also be used in mixtures with known herbicides, finished formulations or tank mixtures being possible.

Suitable herbicides for the mixtures are known herbicides, for example anilides such as, for example, diflufenican and propanil; arylcarboxylic acids such as, for example, dichloropicolinic acid, dicamba and picloram; aryloxyalkanoic acids such as, for example, 2,4-D, 2,4-DB, 2,4-DP, fluroxypyr, MCPA, MCPP and triclopyr; aryloxy-phenoxy-alkanoic esters such as, for example, diclofopmethyl, fenoxapropethyl, fluazifop-butyl, haloxyfop-methyl and quizalofop-ethyl; azinones such as, for example, chloridazon and norflurazon; carbamates such as, for example, chlorpropham, desmedipham, phenmedipham and propham; chloroacetanilides such as, for example, alachlor, acetochlor, butachlor, metazachlor, metolachlor, pretilachlor and propachlor; dinitroanilines such as, for example, oryzalin, pendimethalin and trifluralin; diphenyl ethers such as, for example, acifluorfen, bifenox, fluoroglycofen, fomesafen, halosafen, lactofen and oxyfluorfen; ureas such as, for example, chlortoluron, diuron, fluometuron, isoproturon, linuron and methabenzthiazuron; hydroxylamines such as, for example, alloxydim, clethodim, cycloxydim, sethoxydim and tralkoxydim; imidazolinones such as, for example, imazethapyr, imazamethabenz, imazapyr and imazaquin; nitriles such as, for example, bromoxynil, dichlobenil and ioxynil; oxyacetamides such as, for example, mefenacet; sulphonylureas such as, for example, amidosulfuron, bensulfuron-methyl, chlorimuron-ethyl, chlorsulfuron, cinosulfuron, metsulfuron-methyl, nicosulfuron, primisulfuron, pyrazosulfuron-ethyl, thifensulfuron-methyl, triasulfuron and tribenuron-methyl; thiocarbamates such as, for example, butylate, cycloate, di-allate, EPTC, esprocarb, molinate, prosulfocarb, thiobencarb and tri-allate; triazines such as, for example, atrazine, cyanazine, simazine, simetryn, terbutryn and terbutylazine; triazinones such as, for example, hexazinone, metamitron and metribuzin; others such as, for example, aminotriazole, benfuresate, bentazone, cinmethylin, clomazone, clopyralid, difenzoquat, dithiopyr, ethofumesate, fluorochloridone, glufosinate, glyphosate, isoxaben, pyridate, quinchlorac, quinmerac, sulphosate and tridiphane.

Mixtures with other known active compounds, such as fungicides, insecticides, acaricides, nematicides, bird repellents, plant nutrients and agents which improve soil structure, are also possible.

The active compounds can be used as such, in the form of their formulations or in the use forms prepared therefrom by further dilution, such as ready-to-use solutions, suspensions, emulsions, powders, pastes and granules. They are used in the customary manner, for example by watering, spraying, atomizing or scattering.

The active compounds according to the invention can be applied either before or after emergence of the plants. They can also be incorporated into the soil before sowing.

The amount of active compound used can vary within a substantial range. It depends essentially on the nature of the desired effect. In general, the amounts used are between 10 g and 10 kg of active compound per hectare of soil surface, preferably between 50 g and 5 kg per ha.

The preparation and use of the active compounds according to the invention can be seen from the following examples.

PREPARATION EXAMPLES Example 1 ##STR851##

(Process (a))

1.8 g (10 mMol) of ethyl 3-amino-4,4,4-trifluorocrotonate are introduced into 30 ml of dimethylformamide and 2 ml of toluene, and 0.3 g (10 mMol) of sodium hydride (80%) is added at 0° C. to 5° C. The mixture is stirred for 30 minutes at 0° C. to 5° C. After the mixture has been cooled to -70° C., 0.9 g (5 mMol) of 4-cyano-2,5-difluoro-phenyl isocyanate--dissolved in 10 ml of toluene--are added and the mixture is stirred for 150 minutes at -60° C. to -70° C. After the cooling bath has been removed, 2 ml of acetic acid are added. The mixture is then diluted with water to approximately twice its volume and extracted using ethyl acetate. The organic phase is concentrated, and the residue is crystallized using diisopropyl ether.

1,1 g (69% of theory) of 1-(4-cyano-2,5-difluoro-phenyl)-3,6-dihydro-2,6-dioxo-4-trifluoromethyl-1(2H)-pyrimidine of melting point 194° C. are obtained.

Example 2 ##STR852##

(process (b))

A mixture of 3.2 g (10 mMol) of 1-(4-cyano-2,5-difluoro-phenyl)-3,6-dihydro-2,6-dioxo-4-trifluoromethyl-1(2H)-pyrimidine, 3.1 g (20 mMol) of diethyl sulphate, 2.8 g of potassium carbonate and 100 ml of acetonitrile is refluxed for 3 hours. It is then concentrated in vacuo and extracted by shaking with water/chloroform, and the organic phase, again, is concentrated in vacuo, and the residue is separated by column chromatography (silica gel, petroleum ether/ethyl acetate 1:1).

The first fraction obtained is 0.30 g of 1-(4-cyano-2,5-difluoro-phenyl)-1,6-dihydro-2-ethoxy-6-oxo-4-trifluoro-methyl-pyrimidine (amorphous) and the second fraction is 0.38 g of 1-(4-cyano-2,5-difluoro-phenyl)-3,6-dihydro-2,6-dioxo-3-ethyl-4-trifluoromethyl-1(2H)-pyrimidine (amorphous, ¹ H-NMR: d=6.36 ppm). Total yield: 0.68 g (20% of theory).

Example 3 ##STR853##

(Process (c))

A mixture of 0.83 g (3 mMol) 1-(4-cyano-2,5-difluoro-phenyl)-3,6-dihydro-2,6-dioxo-3,4-dimethyl-1(2H)-pyrimidine, 0.32 g (3 mMol) of methanesulfonamide, 0.6 g of potassium carbonate and 10 ml of dimethyl sulphoxide is heated for 10 hours at 120° C. After the mixture has been cooled, it is poured into ice-water and acidified using 2N-hydrochloric acid. It is then extracted using ethyl acetate, and the organic phase is washed with water, dried using sodium sulphate and filtered. The solvent is carefully removed from the filtrate by distillation under a water pump vacuum.

0.8 g (76% of theory) of 1-(4-cyano-2-fluoro-5-methylsulphonylaminophenyl)-3,6-dihydro-2,6-dioxo-3,4-dimethyl-1(2H)-pyrimidine is obtained as a crystalline residue (melting point>250° C.).

Examples of the compounds of the formula (I) or of the formulae (IA) and (IB) which can be prepared analogously to Examples 1 to 3 and following the general description of the preparation processes according to the invention are those listed in Table 2 below. ##STR854##

                                      TABLE 2                                      __________________________________________________________________________     Examples of the compounds of the formula (I)                                      Gen.                                                                        Ex.                                                                               for-                         melting                                        no.                                                                               mula                                                                              R.sup.1                                                                          R.sup.2 R.sup.3                                                                           R.sup.4                                                                             R.sup.5 point (° C.)                            __________________________________________________________________________     4  IA F F       H  CH.sub.3                                                                            H       273                                            5  IA F F       H  CH.sub.3                                                                            CH.sub.3                                                                               264                                            6  IA F F       H  CH.sub.3                                                                            CHF.sub.2                                              7  IA F F       H  CH.sub.3                                                                            NH.sub.2                                               8  IA F NHSO.sub.2 C.sub.2 H.sub.5                                                             H  CH.sub.3                                                                            CH.sub.3                                                                               .sup.1 H--NMR:                                                                 d = 5.76 ppm                                   9  IA F NHSO.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            CHF.sub.2                                              10 IA F NHSO.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            NH.sub.2                                               11 IA H NHSO.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            NH.sub.2                                               12 IA F F       H  CF.sub.3                                                                            CH.sub.3                                                                               155                                            13 IA F F       H  CF.sub.3                                                                            C.sub.3 H.sub.7                                        14 IA Cl                                                                               F       CH.sub.3                                                                          CF.sub.3                                                                            CHF.sub.2                                              15 IA F NHSO.sub.2 CH.sub.3                                                                    H  CF.sub.3                                                                            CH.sub.3                                               16 IA F NHSO.sub.2 C.sub.2 H.sub.5                                                             H  CF.sub.3                                                                            C.sub.2 h.sub.5                                        17 IA F                                                                                        H  CF.sub.3                                                                            CHF.sub.2                                              18 IA F NHSO.sub.2 CH.sub.3                                                                    H  CF.sub.3                                                                            NH.sub.2                                               19 IA F NHSO.sub.2 C.sub.2 H.sub.5                                                             H  CH.sub.2 Cl                                                                         CH.sub.3                                               20 IA F F       H  CF.sub.2 CF.sub.3                                                                   H       172                                            21 IA F F       H  CF.sub.2 CF.sub.3                                                                   CH.sub.3                                                                               97                                             22 IA H F       H  CF.sub.2 CF.sub.3                                                                   C.sub.2 H.sub.5                                        23 IA H F       H  CF.sub.2 CF.sub.3                                                                   CH.sub.2 CH═CH.sub.2                               24 IA F NHSO.sub.2 CH.sub.3                                                                    H  CF.sub.2 CF.sub.3                                                                   CH.sub.3                                               25 IA F NHSO.sub.2 C.sub.2 H.sub.5                                                             H  CF.sub.2 CF.sub.3                                                                   CH.sub.3                                               26 IA F F       H  CHF.sub.2                                                                           H                                                      27 IA F F       H  CHF.sub.2                                                                           CH.sub.3                                               28 IA F F       H  CHF.sub.2                                                                           CHF.sub.2                                              29 IA F F       H  CHF.sub.2                                                                           NH.sub.2                                               30 IA F NHSO.sub.2 CH.sub.3                                                                    H  CHF.sub.2                                                                           CH.sub.3                                                                               188                                            31 IA F NHSO.sub.2 CH.sub.3                                                                    H  CHF.sub.2                                                                           CHF.sub.2                                              32 IA F NHSO.sub.2 CH.sub.3                                                                    H  CHF.sub.2                                                                           NH.sub.2                                               33 IA F NHSO.sub.2 C.sub.2 H.sub.5                                                             Cl CHF.sub.2                                                                           CH.sub.2 CH═CH.sub.2                               34 IB F F       H  CF.sub.3                                                                            CH.sub.3                                                                               .sup.1 H-NMR:                                                                  d = 6.92 ppm                                   35 IB F F       H  CF.sub.2 CF.sub.3                                                                   CH.sub.3                                                                               116                                            36 IB F NHSO.sub.2 CH.sub.3                                                                    H  CF.sub.3                                                                            CH.sub.3                                                                               192                                            37 IB F NHSO.sub.2 C.sub.2 H.sub.5                                                             H  CF.sub.3                                                                            CH.sub.3                                               38 IB F NHSO.sub.2 CH.sub.3                                                                    H  CF.sub.3                                                                            C.sub.2 H.sub.5                                        39 IB F NHSO.sub.2 C.sub.2 H.sub.5                                                             H  CF.sub.2 CF.sub.3                                                                   CH.sub.3                                               40 IB F NHSO.sub.2 C.sub.3 H.sub.7                                                             H  CF.sub.3                                                                            CH.sub.3                                               41 IA F NHSO.sub.2 CF.sub.3                                                                    H  CH.sub.3                                                                            CH.sub.3                                               42 IA F NHSO.sub.2 CH.sub.3                                                                    H  CF.sub.3                                                                            H       248                                            43 IA F                                                                                 ##STR855##                                                                            H  CF.sub.3                                                                            CH.sub.3                                                                               115                                            44 IA F NHSO.sub.2 C.sub.2 H.sub.5                                                             H  CF.sub.3                                                                            H       228                                            45 IA F                                                                                 ##STR856##                                                                            H  CF.sub.3                                                                            H       49                                             46 IA F                                                                                 ##STR857##                                                                            H  CF.sub.3                                                                            CH.sub.3                                                                               162                                            47 IA F NHSO.sub.2 C.sub.3 H.sub.7                                                             H  CF.sub.3                                                                            H       154                                            48 IA F                                                                                 ##STR858##                                                                            H  CF.sub.3                                                                            C.sub.2 H.sub.5                                                                        177                                            49 IA F                                                                                 ##STR859##                                                                            H  CF.sub.3                                                                            H       .sup.1 H--NMR:  6.5 ppm                        50 IA F                                                                                 ##STR860##                                                                            H  CF.sub.3                                                                            CH.sub.3                                                                               .sup.1 H--NMR:  6.4 ppm                        51 IA F NHSO.sub.2 C.sub.2 H.sub.5                                                             H  CHF.sub.2                                                                           H       258                                            52 IA F                                                                                 ##STR861##                                                                            H  CHF.sub.2                                                                           CH.sub.3                                                                               173                                            53 IA F NHSO.sub.2 C.sub.6 H.sub.5                                                             H  CF.sub.3                                                                            H       253                                            54 IA F                                                                                 ##STR862##                                                                            H  CF.sub.3                                                                            CH.sub.3                                                                               136                                            55 IA F NHSO.sub.2 CH.sub.3                                                                    H  CF.sub.3                                                                            CHF.sub.2                                                                              230                                            56 1A F NHSO.sub.2 CH(CH.sub.3).sub.2                                                          H  CF.sub.3                                                                            H       217                                            57 IA F                                                                                 ##STR863##                                                                            H  CF.sub.3                                                                            CH.sub.3                                                                               163                                            58 IA F NHSO.sub.2 CH.sub.3                                                                    CH.sub.3                                                                          CF.sub.3                                                                            H       229                                            59 IA F                                                                                 ##STR864##                                                                            CH.sub.3                                                                          CF.sub.3                                                                            CH.sub.3                                                                               115                                            60 IA F NHSO.sub.2 CH.sub.3                                                                    H  CHF.sub.2                                                                           H       281                                            61 IA F                                                                                 ##STR865##                                                                            H  CHF.sub.2                                                                           CH.sub.3                                                                               264                                            62 IA F                                                                                 ##STR866##                                                                            H  CF.sub.3                                                                            H       262                                            63 IA F NHSO.sub.2 CH.sub.3                                                                    H  CF.sub.2 Cl                                                                         H       269                                            64 IA F                                                                                 ##STR867##                                                                            H  CF.sub.3                                                                            CH.sub.3                                                                               150                                            65 IA F                                                                                 ##STR868##                                                                            H  CF.sub.2 Cl                                                                         CH.sub.3                                                                               97                                             66 IA F NHSO.sub.2 CH.sub.3                                                                    H  CF.sub.2 Cl                                                                         CH.sub.3                                                                               206                                            67 IA F                                                                                 ##STR869##                                                                            H  CF.sub.3                                                                            CH.sub.3                                                                               180                                            __________________________________________________________________________

Starting substances of the formula (III):

Example (III-1) ##STR870##

660 g of phosgene are condensed into 1.6 liters of chlorobenzene at -5° C. to 0° C. At the same temperature, a solution of 400 g of 4-cyano-2,5-difluoro-aniline in 800 ml of chlorobenzene is added dropwise in the course of 60 minutes. The reaction mixture is subsequently heated up slowly (HCl evolution!) to 120° C., and, after a temperature of 80° C. has been reached, phosgene is passed in continuously. After heating for 1 hour at 120° C., excess phosgene is purged using nitrogen and the reaction mixture is worked up by means of distillation.

248 g (53% of theory) of 4-cyano-2,5-difluoro-phenyl isocyanate of boiling point 108-110° C./14 mbar (melting point: 53° C.) are obtained.

Starting materials of the formula (IV):

Example (IV-1) ##STR871##

13.0 g (0.05 mol) of ethyl chloroformate are added dropwise to a mixture of 11.5 g (0.05 mol) of 4-cyano-2-fluoro-5-methylsulphonylaminoaniline, 18 g of pyridine and 400 ml of methylene chloride at 20° C. while stirring, and the reaction mixture is stirred for a further 30 minutes at 20° C. to 30° C. Thereafter the mixture is washed with water, then with 5% strength hydrochloric acid and again with water, dried with sodium sulphate and filtered, and the filtrate is evaporated down. The remaining residue is digested with a little ethyl acetate, and the product obtained in crystalline form is isolated by filtration with suction.

15.8 g (85% of theory) of N-ethoxycarbonyl-N-(2-cyano-4-fluoro-5-ethoxycarbonylamino-phenyl)-methanesulphonamide of melting point 129° C. are obtained.

For example, the compounds of the formula (IV) shown in Table 3 below may also be prepared analogously to Example (IV-1). ##STR872##

                                      TABLE 3                                      __________________________________________________________________________     Examples of compounds of the formula (IV)                                                                    melting point                                    Ex. no.    R   R.sup.1                                                                            R.sup.2    (° C.)                                    __________________________________________________________________________                    IV-2                                                                               CH.sub.3   H                                                 ##STR873##                                                                               129 IV-3                                                                               C.sub.2 H.sub.5                                                                           F                                                 ##STR874##                                                                               140 IV-4                                                                               C.sub.2 H.sub.5                                                                           F                                                 ##STR875##    IV-5                                                                               CH.sub.3   F                                                 ##STR876##    IV-6                                                                               CH.sub.3   F                                                 ##STR877##    IV-7                                                                               CH.sub.3   F                                                 ##STR878##    IV-8                                                                               CH.sub.3   F                                                 ##STR879##    IV-9                                                                               CH.sub.3   F                                                 ##STR880##    IV-10                                                                              CH.sub.3   F                                                 ##STR881##    IV-11                                                                              CH.sub.3   F                                                IV-12      C.sub.2 H.sub.5                                                                    F                                                                                   ##STR882##                                                                               178                                              IV-13      C.sub.2 H.sub.5                                                                    F                                                                                   ##STR883##                                                                               92                                               IV-14      C.sub.2 H.sub.5                                                                    F                                                                                   ##STR884##                                                                               109                                              IV-15      C.sub.2 H.sub.5                                                                    F                                                                                   ##STR885##                                                                               158                                              IV-16      C.sub.2 H.sub.5                                                                    F                                                                                   ##STR886##                                                                               142                                              __________________________________________________________________________

Use Examples Example A

Pre-emergence test

Solvent: 5 parts by weight of acetone

Emulsifier: 1 part by weight of alkylaryl polyglycol ether

To produce a suitable preparation of active compound, 1 part by weight of active compound is mixed with the stated amount of solvent, the stated amount of emulsifier is added and the concentrate is diluted with water to the desired concentration.

Seeds of the test plants are sown in normal soil and, after 24 hours, watered with the preparation of the active compound. It is expedient to keep constant the amount of water per unit area. The concentration of the active compound in the preparation is of no importance, only the amount of active compound applied per unit area being decisive. After three weeks, the degree of damage to the plants is rated in % damage in comparison to the development of the untreated control. The figures denote:

0%=no action (like untreated control)

100%=total destruction

In this test, the compounds of preparation examples 2 (2nd fraction) and 12, for example, show a very potent activity against weeds, while being well-tolerated by crop plants, such as, for example, maize.

Example B

Post-emergence test

Solvent: 5 parts by weight of acetone

Emulsifier: 1 part by weight of alkylaryl polyglycol ether

To produce a suitable preparation of active compound, 1 part by weight of active compound is mixed with the stated amount of solvent, the stated amount of emulsifier is added and the concentrate is diluted with water to the desired concentration. Test plants which have a height of 5-15 cm are sprayed with the preparation of the active compound in such a way as to apply the particular amounts of active compound desired per unit area. After three weeks, the degree of damage to the plants is rated in % a damage in comparison to the development of the untreated control. The figures denote:

0%=no action (like untreated control)

100%=total destruction

In this test, the compounds of preparation examples 2 (2nd fraction) and 12, for example, show potent activity against weeds, while being well tolerated by crop plants, such as, for example, wheat.

It will be understood that the specification and examples are illustrative but not limitative of the present invention and that other embodiments within the spirit and scope of the invention will suggest themselves to those skilled in the art. 

What is claimed is:
 1. A N-cyanoaryl-nitrogen heterocycle of the formula ##STR887## wherein R¹ represents hydrogen or halogen,R² represents halogen, cyano, or amino R³ represents hydrogen, halogen, cyano or optionally substituted alkyl, R⁴ represents optionally substituted alkyl or together with R³ represents alkanediyl, Z represents one of the groups below ##STR888## in which R⁵ represents in each case optionally substituted alkyl, alkenyl, alkinyl, alkylcarbonyl or alkoxycarbonyl,or a salt thereof.
 2. A N-cyanoaryl-nitrogen heterocycle according to claim 1, whereinR¹ is hydrogen, fluorine, chlorine or bromine, R² is fluorine, chlorine, bromine, cyano or amino, R³ is hydrogen, fluorine, chlorine, bromine, cyano or alkyl having 1 to 6 carbon atoms which is optionally substituted by at least one of fluorine and chlorine, R⁴ is alkyl having 1 to 6 carbon atoms which is optionally substituted by fluorine, chlorine, bromine, methoxy or ethoxy,or together with R³ is alkanediyl having 2 to 8 carbon atoms, and ##STR889## in which R⁵ is alkyl, alkenyl, alkinyl, alkoxycarbonyl, each of which has up to 6 carbon atoms and each of which is optionally substituted by fluorine, bromine, cyano, C₁ -C₄ -alkoxy, C₁ -C₄ -alkyl-carbonyl or C₁ -C₄ -alkoxycarbonyl, or a salt thereof.
 3. A N-cyanoaryl-nitrogen heterocycle according to claim 1, whereinR¹ is hydrogen, fluorine or chlorine, R² is fluorine, chlorine, bromine, cyano or amino, R³ is hydrogen, fluorine, chlorine, bromine, methyl, trifluoromethyl, ethyl or n- or i-propyl, R⁴ is methyl, ethyl, n- or i-propyl, each of which is optionally substituted by fluorine or chlorine,or together with R³ is trimethylene or tetramethylene, and Z is ##STR890## in which R⁵ is methyl, ethyl, n- or i-propyl, n-, i- or s-butyl, propenyl, butenyl, propinyl, butinyl, acetyl, propionyl, methoxycarbonyl or ethoxycarbonyl, each of which is optionally substituted by fluorine, chlorine or cyano, or a salt thereof with a base selected from the group consisting of sodium, potassium and calcium hydroxide, hydride, amide or carbonate, a sodium or potassium C₁ -C₄ -alkanolate, ammonia, a C₁ -C₄ -alkylamine, di-(C₁ -C₄ -alkyl)-amine, tri-(C₁ -C₄ -alkyl)-amine and tris-(2-hydroxyethyl)amine.
 4. A N-cyanoaryl-nitrogen heterocycle according to claim 1, wherein R² is fluorine.
 5. In the cultivation of wheat, corn and soy beans wherein there is applied to the crop or to the field a selective herbicide for killing or preventing growth of unwanted vegetation but not of said crop, the improvement wherein said selective herbicide comprises a compound according to claim 1 or a salt thereof.
 6. A herbicidal composition according to claim 5, wherein such compound is1-(4-cyano-2,5-difluoro-phenyl)-3,6-dihydro-2,6-dioxo-3-ethyl-4-trifluoromethyl-1(2H)-pyrimidine or 1-(4-cyano-2,5-difluoro-phenyl)-3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H)-pyrimidine.
 7. In the cultivation of wheat, corn and soy beans according to claim 5, wherein such compound is1-(4-cyano-2,5-difluoro-phenyl)-3,6-dihydro-2,6-dioxo-3-ethyl-4-trifluoromethyl-1(2H)-pyrimidine or 1-(4-cyano-2,5-difluoro-phenyl)-3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1 (2H) -pyrimidine.
 8. A N-cyanoaryl-nitrogen heterocycle according to claim 1, wherein R³ is hydrogen.
 9. A N-cyanoaryl-nitrogen heterocycle according to claim 1, wherein R⁴ is methyl trisubstituted by fluorine.
 10. A N-cyanoaryl-nitrogen heterocycle according to claim 1, wherein R⁵ is methyl.
 11. A N-cyanoaryl-nitrogen heterocycle according to claim 2, wherein R³ is hydrogen, R⁴ is methyl trisubstituted by fluorine and R⁵ is methyl.
 12. A N-cyanoaryl-nitrogen heterocycle according to claim 4, wherein R³ is hydrogen, R⁴ is methyl trisubstituted by fluorine and R⁵ is methyl.
 13. A compound according to claim 1, wherein such compound is 1-(4-cyano-2,5-difluoro-phenyl)-3,6-dihydro-2,6-dioxo-3-ethyl-4-trifluoromethyl-1(2H)-pyrimidine of the formula ##STR891## or a salt thereof.
 14. A compound according to claim 1 wherein such compound is 1-(4-cyano-2,5-difluoro-phenyl)-3,6-dihydro-2,6-dioxo-3-methyl -4-trifluoromethyl-1(2H)-pyrimidine of the formula ##STR892## or a salt thereof.
 15. A herbicidal composition comprising a herbicidally effective amount of a compound according to claim 1 and a diluent.
 16. A method of combating unwanted vegetation which comprises applying to such vegetation or to a locus from which if is desired to exclude such vegetation a herbicidally effective amount of a compound according to claim
 1. 17. The method according to claim 16, wherein such compound is1-(4-cyano-2,5-difluoro-phenyl)-3,6-dihydro-2,6-dioxo-3-ethyl-4-trifluoromethyl-1(2H)-pyrimidine or 1-(4-cyano-2,5-difluoro-phenyl)-3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H) -pyrimidine. 